Influence of riboflavin and of erythrocyte stroma on glutathione reductase activity in normal, glucose 6 phosphate dehydrogenase deficient and low glutathione reductase individuals

The variability of red cell glutathione reductase was studied as a function of riboflavin administration and of stromal activation in normal, glucose 6 phosphate dehydrogenase deficient and 'low glutathione reductase' individuals. Glutathione reductase level was increased in normal individuals by riboflavin administration or by stromal incubation. However, no glutathione reductase activation could be obtained by riboflavin administration or by incubation with stromata on glucose 6 phosphate dehydrogenase deficient subjects, or by stromata in riboflavin activated glutathione reductase. Low glutathione reductase subjects had riboflavin and stromal activation, but did not show primaquine hemolysis.