Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease

Maria Lucia Eufrasia Vicario, Lorenzo Cirillo, Giovanni Storto, Teresa Pellegrino, Nicola Ragone, Luca Fontanella, Mario Petretta, Domenico Bonaduce, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review


Coronary artery disease (CAD) risk factors influence the hyperemic response in patients without coronary artery stenosis. The aim of this study was to evaluate the influence of risk factors on coronary flow reserve (CFR) estimated by 99mTc-sestamibi cardiac imaging in patients with 1-vessel CAD. Methods: Forty-eight patients with 1-vessel CAD were enrolled in the study. Systemic hypertension, hypercholesterolemia, diabetes mellitus, and cigarette smoking were considered CAD risk factors. Within 48 h, all patients underwent coronary angiography and regional CFR assessment by 99mTc-sestamibi imaging with dipyridamole (0.74 mg/kg of body weight). Eight patients had no risk factors, 14 had 1 risk factor, 18 had 2 risk factors, and 8 had 3 risk factors. Results: The mean ± SD CFR of the narrowed coronary vessel was 1.28 ± 0.43 in the overall study population (1.52 ± 0.30 in patients with 50%-70% stenosis and 0.94 ± 0.75 in patients with >70% stenosis; P <0.001). Two-factor ANOVA showed that the number of risk factors significantly affected CFR (P <0.001) in patients with 50%-70% stenosis, whereas significance was only borderline in patients with >70% stenosis. Finally, a significant interaction among the degree of coronary artery stenosis, the number of risk factors, and the estimated CFR was found (F3 = 14.0; P <0.001). Conclusion: CFR is inversely related to the number of conventional risk factors in patients with 1-vessel CAD and intermediate coronary artery stenosis, whereas this influence is less evident in patients with more severe stenosis.

Original languageEnglish
Pages (from-to)1438-1443
Number of pages6
JournalJournal of Nuclear Medicine
Issue number9
Publication statusPublished - Sep 1 2005


  • Coronary artery disease risk factors
  • Coronary flow reserve
  • Radionuclide cardiac imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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