TY - JOUR
T1 - Influence of selected lifestyle factors on risk of acute myocardial infarction in subjects with familial predisposition for the disease
AU - Tavani, Alessandra
AU - Augustin, Livia
AU - Bosetti, Cristina
AU - Giordano, Laura
AU - Gallus, Silvano
AU - Jenkins, David J A
AU - La Vecchia, Carlo
PY - 2004/4
Y1 - 2004/4
N2 - Background. The joint effect of family history of acute myocardial infarction (AMI) and selected adult life risk factors on the risk of the disease is not clear. Methods. We used the combined data set from three Italian case-control studies including 1,737 cases of incident, nonfatal AMI and 2,317 hospital controls, aged less than 75 years. An adult lifestyle risk score (ALRS) was computed, including tobacco, body mass index, physical activity, and consumption of coffee, alcohol, fish, and vegetables. Results. Compared to the reference category (subjects with no family history of AMI and low ALRS), the risk of AMI was 4.97 (95% confidence intervals, CI: 4.00-6.18) in subjects without family history and high ALRS, 2.19 (95% CI: 1.65-2.90) in subjects with family history and low ALRS, and 11.90 (95% CI: 8.94-15.84) in subjects with family history and high ALRS. Conclusions. The risk of AMI in subjects with a familial predisposition to ischaemic heart disease might be substantially reduced by intervention on selected lifestyle risk factors for AMI. In absolute terms, any such intervention would be more effective than a comparable one on subjects without a familial predisposition.
AB - Background. The joint effect of family history of acute myocardial infarction (AMI) and selected adult life risk factors on the risk of the disease is not clear. Methods. We used the combined data set from three Italian case-control studies including 1,737 cases of incident, nonfatal AMI and 2,317 hospital controls, aged less than 75 years. An adult lifestyle risk score (ALRS) was computed, including tobacco, body mass index, physical activity, and consumption of coffee, alcohol, fish, and vegetables. Results. Compared to the reference category (subjects with no family history of AMI and low ALRS), the risk of AMI was 4.97 (95% confidence intervals, CI: 4.00-6.18) in subjects without family history and high ALRS, 2.19 (95% CI: 1.65-2.90) in subjects with family history and low ALRS, and 11.90 (95% CI: 8.94-15.84) in subjects with family history and high ALRS. Conclusions. The risk of AMI in subjects with a familial predisposition to ischaemic heart disease might be substantially reduced by intervention on selected lifestyle risk factors for AMI. In absolute terms, any such intervention would be more effective than a comparable one on subjects without a familial predisposition.
KW - Acute myocardial infarction
KW - Case-control studies
KW - Diet
KW - Family history
KW - Risk factors
KW - Smoking
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U2 - 10.1016/j.ypmed.2003.11.019
DO - 10.1016/j.ypmed.2003.11.019
M3 - Article
C2 - 15020180
AN - SCOPUS:1542328789
VL - 38
SP - 468
EP - 472
JO - Preventive Medicine
JF - Preventive Medicine
SN - 0091-7435
IS - 4
ER -