Influence of short-term selenium supplementation on the natural course of Hashimoto’s thyroiditis: clinical results of a blinded placebo-controlled randomized prospective trial

D. Esposito, M. Rotondi, G. Accardo, G. Vallone, Giovanni Conzo, S. G. Docimo, F. F. Selvaggi, C. Cappelli, L. Chiovato, D. Giugliano, D. Pasquali

Research output: Contribution to journalArticle

Abstract

Background: The real efficacy of selenium supplementation in Hashimoto’s thyroiditis (HT) is still an unresolved issue. Objectives: We studied the short-term effect of l-selenomethionine on the thyroid function in euthyroid patients with HT. Our primary outcome measures were TSH, thyroid hormones, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) levels and thyroid echogenicity after 6 months of l-selenomethionine treatment. The secondary outcome measure was serum CXCL10 levels. Methods: In a placebo-controlled randomized prospective study, we have enrolled untreated euthyroid patients with HT. Seventy-six patients were randomly assigned to receive l-selenomethionine 166 µg/die (SE n = 38) or placebo (controls n = 38) for 6 months. TSH, free T4 (FT4), free T3 (FT3), TPOAb and CXCL10 serum levels were assayed at time 0, after 3 and 6 months. An ultrasound examination of the left and right thyroid lobe in transverse and longitudinal sections was performed. A rectangular region, the region of interest, was selected for analysis. Results: TSH, FT4, FT3, TPOAb, thyroid echogenicity and CXCL10 were not statistically different between SE and control groups at time 0, after 3 and 6 months. In the SE group, FT4 levels were significantly decreased (P < 0.03) after 3 months, while FT3 increased (P < 0.04) after 3 and 6 months versus baseline values. In the control group, the FT3 decreased after 3 and 6 months (P < 0.02) compared to baseline. Conclusion: The short-term l-selenomethionine supplementation has a limited impact on the natural course in euthyroid HT. Our results tip the balance toward the ineffectiveness of short-term l-selenomethionine supplementation in HT.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalJournal of Endocrinological Investigation
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • 1-selenomethionine
  • CXCL 10 levels
  • Hashimoto's thyroiditis
  • Thyroid echogenicity
  • Thyroid function

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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