Funzione della struttura e delle proprieta' chimico-fisiche degli agenti chimici nell'induzione di alterazioni sul dna: nitroclorobenzeni.

C. F. Cesarone; C. Bolognesi; L. Santi

Funzione della struttura e delle proprieta' chimico-fisiche degli agenti chimici nell'induzione di alterazioni sul dna: nitroclorobenzeni.

Translated title of the contribution: Influence of structure and physico-chemical properties of chemical agents in the induction of DNA alterations: nitrochlorobenzenes

C. F. Cesarone, C. Bolognesi, L. Santi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.

Translated title of the contribution	Influence of structure and physico-chemical properties of chemical agents in the induction of DNA alterations: nitrochlorobenzenes
Original language	Italian
Pages (from-to)	1680-1686
Number of pages	7
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	56
Issue number	16
Publication status	Published - Aug 30 1980

ASJC Scopus subject areas

Medicine(all)

Cite this

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abstract = "The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.",

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AU - Santi, L.

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N2 - The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.

AB - The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.

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Funzione della struttura e delle proprieta' chimico-fisiche degli agenti chimici nell'induzione di alterazioni sul dna: nitroclorobenzeni.

Abstract

ASJC Scopus subject areas

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