Funzione della struttura e delle proprieta' chimico-fisiche degli agenti chimici nell'induzione di alterazioni sul dna: nitroclorobenzeni.

Translated title of the contribution: Influence of structure and physico-chemical properties of chemical agents in the induction of DNA alterations: nitrochlorobenzenes

C. F. Cesarone, C. Bolognesi, L. Santi

Research output: Contribution to journalArticle

Abstract

The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.

Original languageItalian
Pages (from-to)1680-1686
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume56
Issue number16
Publication statusPublished - Aug 30 1980

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Picryl Chloride
Dinitrochlorobenzene
Nerve Tissue
Carcinogens
DNA Damage
DNA
Brain
chlorobenzene

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.",
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AU - Santi, L.

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