Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients

Ilaria Guidi, Daniela Galimberti, Eliana Venturelli, Carlo Lovati, Roberto Del Bo, Chiara Fenoglio, Alberto Gatti, Roberto Dominici, Sara Galbiati, Roberta Virgilio, Simone Pomati, Giacomo P. Comi, Claudio Mariani, Gianluigi Forloni, Nereo Bresolin, Elio Scarpini

Research output: Contribution to journalArticle


The distribution of the Glu298Asp polymorphism in NOS3 gene was determined in 405 Italian patients with "probable" Alzheimer's disease (AD) compared with 253 age-matched controls. Total plasma homocysteine (tHcy) levels were evaluated in 97 patients and 23 controls, and were correlated with the Glu298Asp genotype. A significantly increased frequency of the Glu/Glu genotype in late onset AD (LOAD) patients was found. tHcy levels were significantly increased in patients compared with controls and, notably, higher in LOAD than in early onset AD (EOAD). Stratifying by the Glu298Asp genotype, a trend toward an increase of tHcy was present in Glu/Glu homozygous. This wild type genotype seems to be associated with LOAD. tHcy levels are significantly increased in AD compared with controls and, moreover, higher in LOAD than in EOAD, possibly in correlation with the microvascular disease occurring with aging. Besides, a contribution of the Glu/Glu genotype in increasing tHcy levels has been observed.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalNeurobiology of Aging
Issue number6
Publication statusPublished - Jun 2005


  • Alzheimer's disease
  • Endothelial nitric oxide synthase (NOS3)
  • Polymorphism
  • Risk factor
  • Total plasma homocysteine (tHcy)

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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