TY - JOUR
T1 - Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly
AU - Mazzoccoli, Gianluigi
AU - Dagostino, Mariangela Pia
AU - Fontana, Andrea
AU - Grandone, Elvira
AU - Favuzzi, Giovanni
AU - Tiscia, Giovanni
AU - Margaglione, Maurizio
AU - de Matthaeis, Angela
AU - Greco, Antonio
AU - Vendemiale, Gianluigi
PY - 2012/12
Y1 - 2012/12
N2 - Insulin receptor substrate 2 (IRS2) plays a crucial role in the regulation of insulin signaling. Several polymorphisms of the gene encoding IRS2 have been identified. The variant causing Gly1057Asp substitution is relatively frequent in humans and its impact on insulin sensitivity seems to be dependent on age and body weight. The aim of our study was to evaluate the relationships between Gly1057Asp variant and insulin sensitivity assessed by HOMA, and adiposity evaluated by measurement of epicardial fat (EpiF) thickness in the elderly. We studied 87 subjects, 42 men and 45 women, mean age ± SD: 74.23 ± 7.24. years. In the subjects carrying the Gly1057Asp variant of the IRS2 gene we found higher HOMA index values (3.40 ± 1.14 vs. 2.21 ± 1.25, p
AB - Insulin receptor substrate 2 (IRS2) plays a crucial role in the regulation of insulin signaling. Several polymorphisms of the gene encoding IRS2 have been identified. The variant causing Gly1057Asp substitution is relatively frequent in humans and its impact on insulin sensitivity seems to be dependent on age and body weight. The aim of our study was to evaluate the relationships between Gly1057Asp variant and insulin sensitivity assessed by HOMA, and adiposity evaluated by measurement of epicardial fat (EpiF) thickness in the elderly. We studied 87 subjects, 42 men and 45 women, mean age ± SD: 74.23 ± 7.24. years. In the subjects carrying the Gly1057Asp variant of the IRS2 gene we found higher HOMA index values (3.40 ± 1.14 vs. 2.21 ± 1.25, p
KW - Aging
KW - Epicardial fat
KW - Gly1057Asp
KW - Insulin resistance
KW - IRS2
UR - http://www.scopus.com/inward/record.url?scp=84868301036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868301036&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2012.09.005
DO - 10.1016/j.exger.2012.09.005
M3 - Article
C2 - 23018177
AN - SCOPUS:84868301036
VL - 47
SP - 988
EP - 993
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 12
ER -