Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly

Gianluigi Mazzoccoli; Mariangela Pia Dagostino; Andrea Fontana; Elvira Grandone; Giovanni Favuzzi; Giovanni Tiscia; Maurizio Margaglione; Angela de Matthaeis; Antonio Greco; Gianluigi Vendemiale

doi:10.1016/j.exger.2012.09.005

Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly

Gianluigi Mazzoccoli, Mariangela Pia Dagostino, Andrea Fontana, Elvira Grandone, Giovanni Favuzzi, Giovanni Tiscia, Maurizio Margaglione, Angela de Matthaeis, Antonio Greco, Gianluigi Vendemiale

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Insulin receptor substrate 2 (IRS2) plays a crucial role in the regulation of insulin signaling. Several polymorphisms of the gene encoding IRS2 have been identified. The variant causing Gly1057Asp substitution is relatively frequent in humans and its impact on insulin sensitivity seems to be dependent on age and body weight. The aim of our study was to evaluate the relationships between Gly1057Asp variant and insulin sensitivity assessed by HOMA, and adiposity evaluated by measurement of epicardial fat (EpiF) thickness in the elderly. We studied 87 subjects, 42 men and 45 women, mean age ± SD: 74.23 ± 7.24. years. In the subjects carrying the Gly1057Asp variant of the IRS2 gene we found higher HOMA index values (3.40 ± 1.14 vs. 2.21 ± 1.25, p

Original language	English
Pages (from-to)	988-993
Number of pages	6
Journal	Experimental Gerontology
Volume	47
Issue number	12
DOIs	https://doi.org/10.1016/j.exger.2012.09.005
Publication status	Published - Dec 2012

Keywords

Aging
Epicardial fat
Gly1057Asp
Insulin resistance
IRS2

ASJC Scopus subject areas

Ageing
Biochemistry
Cell Biology
Endocrinology
Genetics
Molecular Biology

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Mazzoccoli, G., Dagostino, M. P., Fontana, A., Grandone, E., Favuzzi, G., Tiscia, G., Margaglione, M., de Matthaeis, A., Greco, A., & Vendemiale, G. (2012). Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly. Experimental Gerontology, 47(12), 988-993. https://doi.org/10.1016/j.exger.2012.09.005

Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly. / Mazzoccoli, Gianluigi; Dagostino, Mariangela Pia; Fontana, Andrea; Grandone, Elvira ; Favuzzi, Giovanni ; Tiscia, Giovanni; Margaglione, Maurizio; de Matthaeis, Angela; Greco, Antonio; Vendemiale, Gianluigi.

In: Experimental Gerontology, Vol. 47, No. 12, 12.2012, p. 988-993.

Research output: Contribution to journal › Article › peer-review

Mazzoccoli, G, Dagostino, MP, Fontana, A, Grandone, E , Favuzzi, G , Tiscia, G, Margaglione, M, de Matthaeis, A, Greco, A & Vendemiale, G 2012, 'Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly', Experimental Gerontology, vol. 47, no. 12, pp. 988-993. https://doi.org/10.1016/j.exger.2012.09.005

Mazzoccoli, Gianluigi ; Dagostino, Mariangela Pia ; Fontana, Andrea ; Grandone, Elvira ; Favuzzi, Giovanni ; Tiscia, Giovanni ; Margaglione, Maurizio ; de Matthaeis, Angela ; Greco, Antonio ; Vendemiale, Gianluigi. / Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly. In: Experimental Gerontology. 2012 ; Vol. 47, No. 12. pp. 988-993.

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