Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly

Gianluigi Mazzoccoli, Mariangela Pia Dagostino, Andrea Fontana, Elvira Grandone, Giovanni Favuzzi, Giovanni Tiscia, Maurizio Margaglione, Angela de Matthaeis, Antonio Greco, Gianluigi Vendemiale

Research output: Contribution to journalArticlepeer-review

Abstract

Insulin receptor substrate 2 (IRS2) plays a crucial role in the regulation of insulin signaling. Several polymorphisms of the gene encoding IRS2 have been identified. The variant causing Gly1057Asp substitution is relatively frequent in humans and its impact on insulin sensitivity seems to be dependent on age and body weight. The aim of our study was to evaluate the relationships between Gly1057Asp variant and insulin sensitivity assessed by HOMA, and adiposity evaluated by measurement of epicardial fat (EpiF) thickness in the elderly. We studied 87 subjects, 42 men and 45 women, mean age ± SD: 74.23 ± 7.24. years. In the subjects carrying the Gly1057Asp variant of the IRS2 gene we found higher HOMA index values (3.40 ± 1.14 vs. 2.21 ± 1.25, p

Original languageEnglish
Pages (from-to)988-993
Number of pages6
JournalExperimental Gerontology
Volume47
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Aging
  • Epicardial fat
  • Gly1057Asp
  • Insulin resistance
  • IRS2

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

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