Influence of the spleen on the blood distribution of the colony-forming cells (CFU-C) in man

L. Morra, A. Ponassi, P. Bruzzi, G. B. Parodi, G. Caristo, C. Sacchetti

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of the blood committed granulocyte progenitor cells (CFU-C) before and after epinephrine administration has been studied in 10 normal, 16 splenomegalic and 8 splenectomized subjects through a double-layer agar culture system. A significant increase of the mean values of CFU-C per milliliter of blood has been observed after epinephrine administration in normal and in splenomegalic subjects. In splenectomized patients the baseline mean values of CFU-C per milliliter of blood were higher than those observed in the other groups of subjects, but they did not increase after epinephrine infusion. The concentration of CFU-C per 10 6 total blood leukocytes was the same in all three groups of subjects and it was not modified by epinephrine administration. Our results seem to indicate that the CFU-C are distributed in two blood compartments, the spleen representing an important section of the marginal compartment of the blood CFU-C.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalActa Haematologica
Volume66
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Influence of the spleen on the blood distribution of the colony-forming cells (CFU-C) in man'. Together they form a unique fingerprint.

Cite this