Influence of transdermal scopolamine on cardiac sympathovagal interaction after acute myocardial infarction

Roberto Pedretti, Enrica Colombo, Simona Sarzi Braga, Bruno Carú

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In 41 survivors of acute myocardial infarction (AMI) a prospective study was performed In 2 sequential phases. In phase 1, the role of beroreflex sensitivity and heart rate variability as predictors of Inducible and spontaneous sustained ventricular tacryarrhythmias was evaluated. In phase 2, the effects of trarurdenmal scopolamine on baroreflex sensitivity, spectral and nonspectral measures of heart rate variability were investigated. At a mean follow-up of 10 ± 3 months after AMI, 5 of 41 patients (12%) developed a late arrhythmic event. Of these, all (100%) had inducibility of sustained monomorphic ventricular tachycardia at programmed stimulation compared with 3 of 36 patients (8%) without events (p -0.0001). At multivariate analysis, baroreflex sensitivity had the strongest relation to both Inducibility of sustained monomorphic ventricular tachycardia (p

Original languageEnglish
Pages (from-to)384-392
Number of pages9
JournalThe American Journal of Cardiology
Issue number5
Publication statusPublished - Aug 15 1993


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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