Influence of triphasic oral contraceptives on blood rheology and hemostatic and metabolic patterns in young women: Results of a three-year study

S. B. Solerte, M. Fioravanti, A. Spinillo, E. Ferrari, S. Guaschino

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term (three-year) variations in clinical, hemorheologic, hemostatic and blood lipid parameters were evaluated in 20 young healthy women taking a triphasic oral contraceptive. Body weight, arterial blood pressure, whole blood, plasma and serum viscosity, erythrocyte deformability, fibrinogen, fibronectin, α-2 macroglobulin, Von Willebrand factor antigen, triglycerides, nonesterified fatty acids, total and low density lipoprotein cholesterol, very low density lipoprotein, low density lipoprotein and apolipoprotein B levels remained unchanged throughout the study. However, high density lipoprotein cholesterol, high density lipoprotein and apolipoprotein A1 serum concentrations increased significantly during treatment. Long-term use of the triphasic oral contraceptive does not seem to adversely affect the blood rheology pattern or vascular endothelium function, which are the main factors responsible for the development of thromboembolic complications.

Original languageEnglish
Pages (from-to)725-732
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume37
Issue number8
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Influence of triphasic oral contraceptives on blood rheology and hemostatic and metabolic patterns in young women: Results of a three-year study'. Together they form a unique fingerprint.

Cite this