TY - JOUR
T1 - Influence of universal HBV vaccination on chronic HBV infection in Italy
T2 - Results of a cross-sectional multicenter study
AU - Sagnelli, Evangelista
AU - Stroffolini, Tommaso
AU - Sagnelli, Caterina
AU - Morisco, Filomena
AU - Coppola, Nicola
AU - Smedile, Antonina
AU - Pisaturo, Mariantonietta
AU - Colloredo, Guido
AU - Babudieri, Sergio
AU - Licata, Anna
AU - Brancaccio, Giuseppina
AU - Andriulli, Angelo
AU - Almasio, Piero Luigi
AU - Gaeta, Giovani B.
AU - Gaeta, Giovanni Battista
AU - Cacopardo, Bruno
AU - De Luca, Massimo
AU - Furlan, Caterina
AU - Pirisi, Mario
AU - Rosina, Floriano
AU - Russello, Maurizio
AU - Santantonio, Teresa
AU - on behalf of the EPACRON study group
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background and Aim: The universal hepatitis B vaccination for infants and 12-year-old adolescents (the latter limited to the first 12 years of application) was launched in Italy in 1991. Twenty-three years later we evaluated the impact of the vaccination campaign on the burden of HBsAg-positive chronic liver diseases (CLD). Material and Methods: A total of 513 HBsAg-positive chronic carriers referring to 16 Italian liver units were investigated and compared with HBsAg carriers enrolled in previous surveys. Results: The proportion of inactive carriers decreased from 20.0% in 2001 to 3.3% in 2014, while that of cirrhotic patients increased from 22.6% to 33.2%. Regarding the age class 0-33 (fully covered by HBV vaccination in 2014), the rate of inactive carriers decreased from the 21.7% in 2001 to 5.9% in 2014, that of chronic hepatitis from 17.5% to 5.2% and that of cirrhosis cases from 26.4% to 4.1%. Instead, in the over-60 age group the rate of inactive carriers increased from 22.8% to 41.2% and that of chronic hepatitis from 16.8% to 46%; the rate of patients with cirrhosis ranged from 5% to 8% in different studies. Conclusion: Twenty-three years after the introduction universal HBV vaccination in Italy, the clinical presentation of CLD had shown a shift toward older ages and more severe diseases.
AB - Background and Aim: The universal hepatitis B vaccination for infants and 12-year-old adolescents (the latter limited to the first 12 years of application) was launched in Italy in 1991. Twenty-three years later we evaluated the impact of the vaccination campaign on the burden of HBsAg-positive chronic liver diseases (CLD). Material and Methods: A total of 513 HBsAg-positive chronic carriers referring to 16 Italian liver units were investigated and compared with HBsAg carriers enrolled in previous surveys. Results: The proportion of inactive carriers decreased from 20.0% in 2001 to 3.3% in 2014, while that of cirrhotic patients increased from 22.6% to 33.2%. Regarding the age class 0-33 (fully covered by HBV vaccination in 2014), the rate of inactive carriers decreased from the 21.7% in 2001 to 5.9% in 2014, that of chronic hepatitis from 17.5% to 5.2% and that of cirrhosis cases from 26.4% to 4.1%. Instead, in the over-60 age group the rate of inactive carriers increased from 22.8% to 41.2% and that of chronic hepatitis from 16.8% to 46%; the rate of patients with cirrhosis ranged from 5% to 8% in different studies. Conclusion: Twenty-three years after the introduction universal HBV vaccination in Italy, the clinical presentation of CLD had shown a shift toward older ages and more severe diseases.
KW - chronic hepatitis B
KW - HBsAg chronic carriers
KW - HBsAg-positive chronic hepatitis
KW - HBsAg-positive chronic hepatitis clinical presentation
KW - HBV vaccination
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U2 - 10.1002/jmv.24873
DO - 10.1002/jmv.24873
M3 - Article
AN - SCOPUS:85031096569
VL - 89
SP - 2138
EP - 2143
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 12
ER -