Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells

S. Pastore, L. De Vecchis, G. Migliorati, L. Frati, A. Giuliani Bonmassar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vindesine (VDS), a structural analogue of Vinca Alkaloids, was found to increase the NK-mediated cytolytic effects of mouse lymphocytes against human K562 target cells in a 18-hr assay. Pretreatment of effector or target cells with the drug did not affect substantially the NK reaction. The phenomenon has been detected using splenocytes of either congenitally a-thymic or conventional euthymic mice of different strains. Effector lymphocytes deprived of cells adherent to plastic surface or to nylon-wool column were still competent for drug-mediated increase of NK function. It is suggested that modification of the membrane make-up of effector or target cells re-versibly induced by VDS, would promote higher NK-mediated cytolytic effects.

Original languageEnglish
Pages (from-to)183-197
Number of pages15
JournalImmunopharmacology and Immunotoxicology
Volume4
Issue number3
DOIs
Publication statusPublished - 1982

Fingerprint

Vindesine
Lymphocytes
Cytotoxicity
Vinca Alkaloids
Nylons
Wool
Pharmaceutical Preparations
Assays
K562 Cells
Plastics
Membranes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

Cite this

Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells. / Pastore, S.; De Vecchis, L.; Migliorati, G.; Frati, L.; Bonmassar, A. Giuliani.

In: Immunopharmacology and Immunotoxicology, Vol. 4, No. 3, 1982, p. 183-197.

Research output: Contribution to journalArticle

Pastore, S. ; De Vecchis, L. ; Migliorati, G. ; Frati, L. ; Bonmassar, A. Giuliani. / Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells. In: Immunopharmacology and Immunotoxicology. 1982 ; Vol. 4, No. 3. pp. 183-197.
@article{1a16ad66b4694d3081d6daa7be3ccede,
title = "Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells",
abstract = "Vindesine (VDS), a structural analogue of Vinca Alkaloids, was found to increase the NK-mediated cytolytic effects of mouse lymphocytes against human K562 target cells in a 18-hr assay. Pretreatment of effector or target cells with the drug did not affect substantially the NK reaction. The phenomenon has been detected using splenocytes of either congenitally a-thymic or conventional euthymic mice of different strains. Effector lymphocytes deprived of cells adherent to plastic surface or to nylon-wool column were still competent for drug-mediated increase of NK function. It is suggested that modification of the membrane make-up of effector or target cells re-versibly induced by VDS, would promote higher NK-mediated cytolytic effects.",
author = "S. Pastore and {De Vecchis}, L. and G. Migliorati and L. Frati and Bonmassar, {A. Giuliani}",
year = "1982",
doi = "10.3109/08923978209026433",
language = "English",
volume = "4",
pages = "183--197",
journal = "Immunopharmacology and Immunotoxicology",
issn = "0892-3973",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells

AU - Pastore, S.

AU - De Vecchis, L.

AU - Migliorati, G.

AU - Frati, L.

AU - Bonmassar, A. Giuliani

PY - 1982

Y1 - 1982

N2 - Vindesine (VDS), a structural analogue of Vinca Alkaloids, was found to increase the NK-mediated cytolytic effects of mouse lymphocytes against human K562 target cells in a 18-hr assay. Pretreatment of effector or target cells with the drug did not affect substantially the NK reaction. The phenomenon has been detected using splenocytes of either congenitally a-thymic or conventional euthymic mice of different strains. Effector lymphocytes deprived of cells adherent to plastic surface or to nylon-wool column were still competent for drug-mediated increase of NK function. It is suggested that modification of the membrane make-up of effector or target cells re-versibly induced by VDS, would promote higher NK-mediated cytolytic effects.

AB - Vindesine (VDS), a structural analogue of Vinca Alkaloids, was found to increase the NK-mediated cytolytic effects of mouse lymphocytes against human K562 target cells in a 18-hr assay. Pretreatment of effector or target cells with the drug did not affect substantially the NK reaction. The phenomenon has been detected using splenocytes of either congenitally a-thymic or conventional euthymic mice of different strains. Effector lymphocytes deprived of cells adherent to plastic surface or to nylon-wool column were still competent for drug-mediated increase of NK function. It is suggested that modification of the membrane make-up of effector or target cells re-versibly induced by VDS, would promote higher NK-mediated cytolytic effects.

UR - http://www.scopus.com/inward/record.url?scp=84907115874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907115874&partnerID=8YFLogxK

U2 - 10.3109/08923978209026433

DO - 10.3109/08923978209026433

M3 - Article

VL - 4

SP - 183

EP - 197

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

SN - 0892-3973

IS - 3

ER -