Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells

S. Pastore, L. de Vecchis, G. Migliorati, L. Frati, A. G. Bonmassar

Research output: Contribution to journalArticle

Abstract

Vindesine (VDS), a structural analogue of Vinca Alkaloids, was found to increase the NK-mediated cytolytic effects of mouse lymphocytes against human K562 target cells in an 18-hr assay. Pretreatment of effector or target cells with the drug did not affect substantially the NK reaction. The phenomenon has been detected using splenocytes of either congenitally athymic or conventional euthymic mice of different strains. Effector lymphocytes deprived of cells adherent to plastic surface or to nylon-wool column were still competent for drug-mediated increase of NK function. It is suggested that modification of the membrane make-up of effector or target cells reversibly induced by VDS, would promote higher NK-mediated cytolytic effects.

Original languageEnglish
Pages (from-to)183-197
Number of pages15
JournalJournal of Immunopharmacology
Volume4
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology
  • Toxicology
  • Pharmacology

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  • Cite this

    Pastore, S., de Vecchis, L., Migliorati, G., Frati, L., & Bonmassar, A. G. (1982). Influence of vindesine on the lytic phase of mouse natural cytotoxicity against human leukemic cells. Journal of Immunopharmacology, 4(3), 183-197.