Influenza and pneumococcal vaccinations are not associated to COVID-19 outcomes among patients admitted to a university hospital

Roberta Pastorino, Leonardo Villani, Daniele Ignazio La Milia, Roberto Ieraci, Francesco Chini, Enrico Volpe, Alessandra Barca, Danilo Fusco, Patrizia Laurenti, Walter Ricciardi, Stefania Boccia

Research output: Contribution to journalArticlepeer-review

Abstract

In order to reduce the burden on healthcare systems and to support differential diagnosis with COVID-19, influenza and pneumococcal vaccinations were strongly recommended during the COVID-19 pandemic, especially in vulnerable groups. However, no univocal and conclusive evidence on the relationship between influenza and pneumococcal vaccinations and COVID‐19 outcomes exists. We evaluated the association between such vaccinations, COVID-19 hospitalization, intensive care unit admissions and deaths in a cohort (N = 741) of COVID-19 patients who had access to the emergency room of a large Italian University hospital between March 1, 2020 and June 1, 2020. Results show that influenza and pneumococcal vaccinations did not affect hospitalization, intensive care unit admission and deaths in COVID-19 patients in the overall sample and in those ≥65 years. The same pattern of results was confirmed considering timing of influenza vaccine administration, vaccination type, and number of uptakes in the last five vaccination campaigns. In conclusion, our study does not support an impact of influenza and pneumococcal vaccinations on COVID-19 outcomes.

Original languageEnglish
Pages (from-to)3493-3497
Number of pages5
JournalVaccine
Volume39
Issue number26
DOIs
Publication statusPublished - Jun 11 2021

Keywords

  • COVID-19
  • Flu vaccination
  • Health outcomes
  • Pneumococcal vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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