TY - JOUR
T1 - Influenza B-Cells protective epitope characterization
T2 - A passkey for the rational design of new broad-range anti-influenza vaccines
AU - Clementi, Nicola
AU - Criscuolo, Elena
AU - Castelli, Matteo
AU - Mancini, Nicasio
AU - Clementi, Massimo
AU - Burioni, Roberto
PY - 2012/11
Y1 - 2012/11
N2 - The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" anti-influenza vaccines.
AB - The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" anti-influenza vaccines.
KW - Epitope-based influenza vaccine
KW - Heterosubtipic neutralizing activity
KW - Monoclonal antibody
KW - Protective epitopes
UR - http://www.scopus.com/inward/record.url?scp=84870588311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870588311&partnerID=8YFLogxK
U2 - 10.3390/v4113090
DO - 10.3390/v4113090
M3 - Article
C2 - 23202517
AN - SCOPUS:84870588311
VL - 4
SP - 3090
EP - 3108
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 11
ER -