Influenza vaccine in healthy children: A meta-analysis

Eva Negri, Carla Colombo, Laura Giordano, Nicola Groth, Giovanni Apolone, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


We conducted a meta-analysis of 13 randomised clinical trials evaluating the efficacy of influenza vaccine in healthy children. Against culture-confirmed influenza the overall efficacy was 74% (95% confidence interval, CI, 57%-84%), 65% for inactivated and 80% for live-attenuated vaccine. Corresponding figures were 59% (95% CI 43%-71%), 63% and 54% for serologically-confirmed influenza, and 33% (95% CI 29%-36%), 33% and 34% for clinical illness. Influenza vaccine is effective in preventing laboratory-confirmed and clinical influenza in healthy children, with no clear difference between inactivated and live-attenuated vaccine. Data on infants and younger children were too scanty to allow separate assessment.

Original languageEnglish
Pages (from-to)2851-2861
Number of pages11
Issue number22
Publication statusPublished - Apr 22 2005


  • Children
  • Influenza vaccine
  • Meta-analysis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


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