Influenza virus A (H5N1): A pandemic risk?

Muhammed Babakir-Mina, Emanuela Balestra, Carlo Federico Perno, Stefano Aquaro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Influenza A subtype H5N1 has represented a growing alarm since its recent identification in Asia. Previously thought to infect only wild birds and poultry, H5N1 has now infected humans, cats, pigs and other mammals in an ongoing outbreak, often with a fatal outcome. In order to evaluate the risk factors for human infection with influenza virus H5N1, here we summarize 53 case patients confirmed with H5N1 infection during 2006. The review also compares the mortality rate among human cases from late 2003 until 15 June 2006 in different countries, Neither how these viruses are transmitted to humans nor the most effective way to reduce the risk for infection is fully understood, The association between household contact with diseased poultry in human infection has been demonstrated, This association could possibly operate by 2 mechanisms. First, transmission may be by inhalation or conjunctival deposition of large infectious droplets which may travel only in short distances, Second, having infected poultry in the home and preparation of infected poultry for consumption may result in exposure to higher virus concentrations than other types of exposure. There is so far no significant evidence for repeated human to human transmission, yet some cases of human to human transmission among the family relatives in Indonesia, Azerbaijan, Iraq and Turkey have been described. Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 sub-type) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future.

Original languageEnglish
Pages (from-to)65-77
Number of pages13
JournalNew Microbiologica
Volume30
Issue number2
Publication statusPublished - Apr 2007

Fingerprint

Influenza A virus
Pandemics
Poultry
Infection
Human Influenza
Birds
Disease Outbreaks
Poultry Diseases
Azerbaijan
Viruses
Iraq
Influenza in Birds
Fatal Outcome
Indonesia
Turkey
Orthomyxoviridae
Inhalation
Mammals
Cats
Swine

Keywords

  • Avian influenza
  • Pandemic
  • Pathogenicity
  • Transmission

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Babakir-Mina, M., Balestra, E., Perno, C. F., & Aquaro, S. (2007). Influenza virus A (H5N1): A pandemic risk? New Microbiologica, 30(2), 65-77.

Influenza virus A (H5N1) : A pandemic risk? / Babakir-Mina, Muhammed; Balestra, Emanuela; Perno, Carlo Federico; Aquaro, Stefano.

In: New Microbiologica, Vol. 30, No. 2, 04.2007, p. 65-77.

Research output: Contribution to journalArticle

Babakir-Mina, M, Balestra, E, Perno, CF & Aquaro, S 2007, 'Influenza virus A (H5N1): A pandemic risk?', New Microbiologica, vol. 30, no. 2, pp. 65-77.
Babakir-Mina M, Balestra E, Perno CF, Aquaro S. Influenza virus A (H5N1): A pandemic risk? New Microbiologica. 2007 Apr;30(2):65-77.
Babakir-Mina, Muhammed ; Balestra, Emanuela ; Perno, Carlo Federico ; Aquaro, Stefano. / Influenza virus A (H5N1) : A pandemic risk?. In: New Microbiologica. 2007 ; Vol. 30, No. 2. pp. 65-77.
@article{44e010cfd90949c8bebcfec582206b9d,
title = "Influenza virus A (H5N1): A pandemic risk?",
abstract = "Influenza A subtype H5N1 has represented a growing alarm since its recent identification in Asia. Previously thought to infect only wild birds and poultry, H5N1 has now infected humans, cats, pigs and other mammals in an ongoing outbreak, often with a fatal outcome. In order to evaluate the risk factors for human infection with influenza virus H5N1, here we summarize 53 case patients confirmed with H5N1 infection during 2006. The review also compares the mortality rate among human cases from late 2003 until 15 June 2006 in different countries, Neither how these viruses are transmitted to humans nor the most effective way to reduce the risk for infection is fully understood, The association between household contact with diseased poultry in human infection has been demonstrated, This association could possibly operate by 2 mechanisms. First, transmission may be by inhalation or conjunctival deposition of large infectious droplets which may travel only in short distances, Second, having infected poultry in the home and preparation of infected poultry for consumption may result in exposure to higher virus concentrations than other types of exposure. There is so far no significant evidence for repeated human to human transmission, yet some cases of human to human transmission among the family relatives in Indonesia, Azerbaijan, Iraq and Turkey have been described. Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 sub-type) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future.",
keywords = "Avian influenza, Pandemic, Pathogenicity, Transmission",
author = "Muhammed Babakir-Mina and Emanuela Balestra and Perno, {Carlo Federico} and Stefano Aquaro",
year = "2007",
month = "4",
language = "English",
volume = "30",
pages = "65--77",
journal = "New Microbiologica",
issn = "1121-7138",
publisher = "Luigi Ponzio e figlio Editori",
number = "2",

}

TY - JOUR

T1 - Influenza virus A (H5N1)

T2 - A pandemic risk?

AU - Babakir-Mina, Muhammed

AU - Balestra, Emanuela

AU - Perno, Carlo Federico

AU - Aquaro, Stefano

PY - 2007/4

Y1 - 2007/4

N2 - Influenza A subtype H5N1 has represented a growing alarm since its recent identification in Asia. Previously thought to infect only wild birds and poultry, H5N1 has now infected humans, cats, pigs and other mammals in an ongoing outbreak, often with a fatal outcome. In order to evaluate the risk factors for human infection with influenza virus H5N1, here we summarize 53 case patients confirmed with H5N1 infection during 2006. The review also compares the mortality rate among human cases from late 2003 until 15 June 2006 in different countries, Neither how these viruses are transmitted to humans nor the most effective way to reduce the risk for infection is fully understood, The association between household contact with diseased poultry in human infection has been demonstrated, This association could possibly operate by 2 mechanisms. First, transmission may be by inhalation or conjunctival deposition of large infectious droplets which may travel only in short distances, Second, having infected poultry in the home and preparation of infected poultry for consumption may result in exposure to higher virus concentrations than other types of exposure. There is so far no significant evidence for repeated human to human transmission, yet some cases of human to human transmission among the family relatives in Indonesia, Azerbaijan, Iraq and Turkey have been described. Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 sub-type) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future.

AB - Influenza A subtype H5N1 has represented a growing alarm since its recent identification in Asia. Previously thought to infect only wild birds and poultry, H5N1 has now infected humans, cats, pigs and other mammals in an ongoing outbreak, often with a fatal outcome. In order to evaluate the risk factors for human infection with influenza virus H5N1, here we summarize 53 case patients confirmed with H5N1 infection during 2006. The review also compares the mortality rate among human cases from late 2003 until 15 June 2006 in different countries, Neither how these viruses are transmitted to humans nor the most effective way to reduce the risk for infection is fully understood, The association between household contact with diseased poultry in human infection has been demonstrated, This association could possibly operate by 2 mechanisms. First, transmission may be by inhalation or conjunctival deposition of large infectious droplets which may travel only in short distances, Second, having infected poultry in the home and preparation of infected poultry for consumption may result in exposure to higher virus concentrations than other types of exposure. There is so far no significant evidence for repeated human to human transmission, yet some cases of human to human transmission among the family relatives in Indonesia, Azerbaijan, Iraq and Turkey have been described. Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 sub-type) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future.

KW - Avian influenza

KW - Pandemic

KW - Pathogenicity

KW - Transmission

UR - http://www.scopus.com/inward/record.url?scp=34347269633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347269633&partnerID=8YFLogxK

M3 - Article

C2 - 17619249

AN - SCOPUS:34347269633

VL - 30

SP - 65

EP - 77

JO - New Microbiologica

JF - New Microbiologica

SN - 1121-7138

IS - 2

ER -