Information processing in severe disorders of consciousness: Vegetative state and minimally conscious state

B. Kotchoubey, S. Lang, G. Mezger, D. Schmalohr, M. Schneck, A. Semmler, V. Bostanov, N. Birbaumer

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To study the presence of electrophysiological indicators of remaining cortical functions in patients with persistent vegetative state (PVS) and minimally conscious state (MCS). Previous electrophysiological and PET data indicated that some PVS patients have partially intact cortical processing functions. However, it remains unclear whether the reported patients were representative for PVS population or just some exceptional cases. Methods: Event-related brain responses to stimuli of different complexity levels, recorded in 98 patients with extremely severe diffuse brain injuries, 50 of which in PVS. Four main indicators of cortical functions were: (i) N1-P2 complex as an index of simple, undifferentiated cortical processing; (ii) mismatch negativity as an index of pre-attentive, probably unconscious, cortical orientation; (iii) P3 wave as an index of deep cortical analysis of physical stimuli, and (iv) brain responses to semantic stimuli. Results: Cortical responses were found in all PVS patients with a background EEG activity >4 Hz. All responses investigated, including those to semantic stimuli that indicated comprehension of meaning, occurred significantly above chance, though less frequently than in patients with severe brain injuries who were conscious. Conclusions: Cortical responses were lacking in most patients with severe EEG slowing (

Original languageEnglish
Pages (from-to)2441-2453
Number of pages13
JournalClinical Neurophysiology
Volume116
Issue number10
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Consciousness
  • Event-related potentials
  • Minimally conscious state
  • P300
  • Vegetative state

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Information processing in severe disorders of consciousness: Vegetative state and minimally conscious state'. Together they form a unique fingerprint.

Cite this