The data provided by the Progetto Pertosse, a study on 15,601 children immunized with whole-cell or acellular diphtheria-tetanus-pertussis vaccines, or with a diphtheria-tetanus vaccine, allowed to gather detailed information on adverse reactions which can occur after the administration of the acellular vaccines used in Italy. Families of pertussis vaccinees should be informed in detail of expected adverse reactions. The results from Progetto Pertosse show that the reactogenicity of acellular vaccines is much lower than that observed with whole-cell vaccines, and similar to diphtheria- tetanus vaccines. The most common adverse events such as fever and local reactions start and end in most cases within 2 days of administration, and in the majority of cases have a short duration. The simultaneous administration of polio and hepatitis B vaccines does not increase the reactogenicity and does not affect the efficacy of acellular vaccines. Injection in the buttock is associated with a lower probability of observing common adverse reactions when compared to injection in the thigh. Children who experienced an adverse reaction are more likely to present the same event at following doses. Appropriate information to parents of vaccinees on the safety of acellular pertussis vaccines is necessary, it is useful to reassure the families of vaccinees and avoid interruptions of the immunization series due to false contraindications.
|Translated title of the contribution||Information to be provided to parents of children to be vaccinated with diphtheria-tetanus-pertussis acellular vaccine|
|Number of pages||10|
|Publication status||Published - Apr 1999|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health