Abstract
An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset.
| Original language | English |
|---|---|
| Pages (from-to) | 623-628 |
| Number of pages | 6 |
| Journal | Journal of Experimental Medicine |
| Volume | 155 |
| Issue number | 2 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Immunology
Cite this
Caligaris-Cappio, F., Gobbi, M., Bofill, M., & Janossy, G. (1982). Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia. Journal of Experimental Medicine, 155(2), 623-628.