Infusion of in vitro expanded tumour-infiltrating lymphocytes and recombinant interleukin-2 in patients with surgically resected lymph node metastases of malignant melanoma: A pilot study

U. M. Reali, L. Martini, L. Borgognoni, C. Semino, G. Pietra, C. Chiarugi, M. Guastella, G. Melioli

Research output: Contribution to journalArticle

Abstract

A pilot study was set up in order to evaluate the feasibility and safety of infusing in vitro expanded tumour-infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2) in a group of patients with advanced melanoma after radical resection of lymph node metastases. Twenty-four patients were eligible for the study and proliferating TILs were collected in 16. These patients were infused with TILs and then treated with rIL-2 and α-interferon. Short-term toxic effects (such as fever) were in general controlled by symptomatic drugs, whereas chronic toxicities were absent. The median follow-up period was 19 months; at present, 13 patients are alive and disease free, one patient is in progression and two patients have died. The approach was feasible and safe and the clinical results observed are comparable to those obtained by long-term treatment with other biological response modifies.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalMelanoma Research
Volume8
Issue number1
Publication statusPublished - 1998

Keywords

  • Adoptive immunotherapy
  • Recombinant interleukin-2
  • Stage IIIb melanoma
  • Tumour-infiltrating lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

Fingerprint Dive into the research topics of 'Infusion of in vitro expanded tumour-infiltrating lymphocytes and recombinant interleukin-2 in patients with surgically resected lymph node metastases of malignant melanoma: A pilot study'. Together they form a unique fingerprint.

  • Cite this