I corticosteroidi inalatori nel trattamento dell'asma bronchiale: Nuove risposte a vecchi problemi

Translated title of the contribution: Inhaled corticosteroids in the treatment of bronchial asthma: New answers to old problems

Stefano Centanni, Francesca Giovannelli

Research output: Contribution to journalArticlepeer-review

Abstract

Inhaled steroids are the central pharmaceutical agents for the in-depth treatment of bronchial asthma. Diverse molecules are currently available that, though belonging to the same family, have different pharmacokinetic and pharmacodynamic properties. Each molecole, thus, conforms to a greater or lesser extent to the ideal characteristics of this family, namely a high local efficacy accompanied by a low systemic impact. Generally speaking, the new generation inhaled steroids respond better than earlier molecules to these requisites, characterized as they are by a good penetration into the lung, long retention time at the site of infection, low oral absorption and an efficient systemic elimination. It should however be noted that the local and systemic effects of inhaled steroids are mediated by the same receptors; hence the idea of an inhaled steroid with high local efficacy and without undesirable systemic effects does not today seem realistic. Precisely this aspect reveals how important it is today, even with the new generation molecules, to use the lowest dose of inhaled steroid capable of ensuring disease control.

Translated title of the contributionInhaled corticosteroids in the treatment of bronchial asthma: New answers to old problems
Original languageItalian
Pages (from-to)47-49
Number of pages3
JournalMultidisciplinary Respiratory Medicine
Volume3
Issue number1
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Inhaled corticosteroids in the treatment of bronchial asthma: New answers to old problems'. Together they form a unique fingerprint.

Cite this