Inherited Arrhythmogenic Diseases

The Complexity Beyond Monogenic Disorders

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Twelve years after the identification of the molecular bases of the long-QT syndrome, it is now possible to express some considerations on the impact that genetic findings have had in the understanding of inherited arrhythmogenic diseases. Along with the excitement for the emerging data on genotype/phenotype correlation and for the development of the first recommendations for gene-specific management of patients, it is also important to acknowledge the unexpected complexity that has emerged. The focus of this article is to analyze the elusive aspects of the relationship between genetic defects and clinical manifestations and to propose some research directions that may provide the needed answers to move forward in the understanding of the genetics of heart rhythm abnormalities.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalCirculation Research
Volume94
Issue number2
DOIs
Publication statusPublished - Feb 6 2004

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Long QT Syndrome
Congenital Heart Defects
Genetic Association Studies
Research
Genes
Direction compound

Keywords

  • Arrhythmias
  • Genetics
  • Heart
  • Ion channels
  • Sudden cardiac death

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Inherited Arrhythmogenic Diseases : The Complexity Beyond Monogenic Disorders. / Priori, Silvia G.

In: Circulation Research, Vol. 94, No. 2, 06.02.2004, p. 140-145.

Research output: Contribution to journalArticle

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