Inherited Cardiac Arrhythmia Syndrome: Role of Potassium Channels

Lia Crotti, Roberto Insolia, Peter J. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Potassium channels are key players in the control of cardiac action potential, and their dysfunction can lead to atrial and ventricular arrhythmias. Mutations in genes encoding voltage-gated potassium channels, leading to their loss of function, cause long QT syndrome and Andersen-Tawil syndrome. Mutations in potassium-channel genes, leading to their gain of function, cause short QT syndrome and familial atrial fibrillation. Recently, the potassium-channel KATP has been implicated in early repolarization syndrome and in Brugada syndrome.

Original languageEnglish
Pages (from-to)113-124
Number of pages12
JournalCardiac Electrophysiology Clinics
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Arrhythmias
  • Channelopathies
  • Genetics
  • Potassium channels
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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