Inherited Chromosomally Integrated Human Herpesvirus 6: An Unexpected Finding in a Septic Neonate

L. Pugni, C. Pietrasanta, A. Ronchi, G. Lunghi, L. Pellegrinelli, F. Mosca, G. Campanini, F. Baldanti

Research output: Contribution to journalArticlepeer-review

Abstract

Human herpesvirus 6 (HHV-6) can integrate its genome in human chromosomes and be germline transmitted (inherited chromosomally integrated HHV-6). We report a case of chromosomally integrated HHV-6 inherited from the mother unexpectedly diagnosed in a septic neonate. Since HHV-6 has recently been included in multiplex polymerase chain reaction assays for meningitis/encephalitis, diagnosing inherited chromosomally integrated HHV-6 status is essential to avoid misdiagnosis of active HHV-6 infection and unnecessary antiviral treatment. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Original languageEnglish
Pages (from-to)74-75
Number of pages2
JournalPediatric Infectious Disease Journal
Volume40
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • chromosomal integration
  • HHV-6
  • human herpesvirus 6
  • inherited herpesvirus
  • neonatal sepsis

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