Inherited factors in thrombosis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Patients with inherited defects or abnormalities that impair the naturally-occurring anticoagulant and fibrinolytic systems are at risk of developing venous and, more rarely, arterial thromboembolism. The prevalence of inherited thrombophilia in the general population is higher than that of inherited bleeding disorders (ca.1 in 7500 vs 1 in 20 000). Low levels or dysfunctional forms of antithrombin III, protein C and protein S and abnormal fibrinogens are the most frequent and well-established inherited causes for thrombosis. Less frequent and/or less established causes are low heparin cofactor II and plasminogen and high levels of plasminogen activator inhibitor and histidine-rich glycoprotein. The pathophysiology, genetic and clinical aspects and laboratory diagnosis of inherited thrombotic disorders are reviewed and an approach to prophylaxis and therapy is outlined.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalBlood Reviews
Volume2
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Abnormal Fibrinogens
Heparin Cofactor II
Antithrombin Proteins
Plasminogen Inactivators
Thrombophilia
Antithrombin III
Clinical Laboratory Techniques
Plasminogen
Protein S
Thromboembolism
Protein C
Anticoagulants
Thrombosis
Hemorrhage
Population
Therapeutics
histidine-rich proteins

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Inherited factors in thrombosis. / Mannucci, P. M.; Tripodi, A.

In: Blood Reviews, Vol. 2, No. 1, 1988, p. 27-35.

Research output: Contribution to journalArticle

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