Inherited thrombophilia and gestational vascular complications

Elvira Grandone, Maurizio Margaglione

Research output: Contribution to journalArticle

Abstract

The most common causes of inherited thrombophilia, the factor V Leiden and the factor II A20210 mutations, confer a higher risk of venous thromboembolism. Moreover, several studies have suggested that they can have a role in the occurrence of gestational vascular complications in otherwise unexplained recurrent fetal losses, hypertensive disorders of pregnancy and fetal growth restriction. Observational and case-control studies addressing these issues are available in literature. However, longitudinal, perspective studies are lacking. Mild hyperhomocysteinaemia can be due partly to inherited susceptibility-as the homozygous carriership of the T677 variant in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR). Case-control studies have been carried out on a possible association between unexplained fetal losses and mild hyperhomocysteinaemia. Although case-control and perspective studies are available on hyperhomocysteinaemia and other gestational vascular complications the data are conflicting. Intervention studies have been carried out to prevent adverse obstetric outcomes in women with factor V Leiden or factor II A20210 mutations and previous adverse outcomes. Although these are not randomized controlled trials, all have found significantly better outcomes in treated pregnancies compared to those of untreated pregnancies in the same women.

Original languageEnglish
Pages (from-to)321-332
Number of pages12
JournalBest Practice and Research: Clinical Haematology
Volume16
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Hyperhomocysteinemia
Thrombophilia
Blood Vessels
Case-Control Studies
Pregnancy
Obstetrics
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Gene encoding
Venous Thromboembolism
Fetal Development
Longitudinal Studies
Randomized Controlled Trials
Genes
factor V Leiden

Keywords

  • Fetal loss
  • Hyperhomocysteinaemia
  • Pre-eclampsia
  • Pregnancy complications
  • Pregnancy outcome
  • Thrombophilia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Inherited thrombophilia and gestational vascular complications. / Grandone, Elvira; Margaglione, Maurizio.

In: Best Practice and Research: Clinical Haematology, Vol. 16, No. 2, 2003, p. 321-332.

Research output: Contribution to journalArticle

@article{870bfcdce793402580f0ab6751f0ba09,
title = "Inherited thrombophilia and gestational vascular complications",
abstract = "The most common causes of inherited thrombophilia, the factor V Leiden and the factor II A20210 mutations, confer a higher risk of venous thromboembolism. Moreover, several studies have suggested that they can have a role in the occurrence of gestational vascular complications in otherwise unexplained recurrent fetal losses, hypertensive disorders of pregnancy and fetal growth restriction. Observational and case-control studies addressing these issues are available in literature. However, longitudinal, perspective studies are lacking. Mild hyperhomocysteinaemia can be due partly to inherited susceptibility-as the homozygous carriership of the T677 variant in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR). Case-control studies have been carried out on a possible association between unexplained fetal losses and mild hyperhomocysteinaemia. Although case-control and perspective studies are available on hyperhomocysteinaemia and other gestational vascular complications the data are conflicting. Intervention studies have been carried out to prevent adverse obstetric outcomes in women with factor V Leiden or factor II A20210 mutations and previous adverse outcomes. Although these are not randomized controlled trials, all have found significantly better outcomes in treated pregnancies compared to those of untreated pregnancies in the same women.",
keywords = "Fetal loss, Hyperhomocysteinaemia, Pre-eclampsia, Pregnancy complications, Pregnancy outcome, Thrombophilia",
author = "Elvira Grandone and Maurizio Margaglione",
year = "2003",
doi = "10.1016/S1521-6926(03)00017-3",
language = "English",
volume = "16",
pages = "321--332",
journal = "Best Practice and Research in Clinical Haematology",
issn = "1521-6926",
publisher = "Bailliere Tindall Ltd",
number = "2",

}

TY - JOUR

T1 - Inherited thrombophilia and gestational vascular complications

AU - Grandone, Elvira

AU - Margaglione, Maurizio

PY - 2003

Y1 - 2003

N2 - The most common causes of inherited thrombophilia, the factor V Leiden and the factor II A20210 mutations, confer a higher risk of venous thromboembolism. Moreover, several studies have suggested that they can have a role in the occurrence of gestational vascular complications in otherwise unexplained recurrent fetal losses, hypertensive disorders of pregnancy and fetal growth restriction. Observational and case-control studies addressing these issues are available in literature. However, longitudinal, perspective studies are lacking. Mild hyperhomocysteinaemia can be due partly to inherited susceptibility-as the homozygous carriership of the T677 variant in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR). Case-control studies have been carried out on a possible association between unexplained fetal losses and mild hyperhomocysteinaemia. Although case-control and perspective studies are available on hyperhomocysteinaemia and other gestational vascular complications the data are conflicting. Intervention studies have been carried out to prevent adverse obstetric outcomes in women with factor V Leiden or factor II A20210 mutations and previous adverse outcomes. Although these are not randomized controlled trials, all have found significantly better outcomes in treated pregnancies compared to those of untreated pregnancies in the same women.

AB - The most common causes of inherited thrombophilia, the factor V Leiden and the factor II A20210 mutations, confer a higher risk of venous thromboembolism. Moreover, several studies have suggested that they can have a role in the occurrence of gestational vascular complications in otherwise unexplained recurrent fetal losses, hypertensive disorders of pregnancy and fetal growth restriction. Observational and case-control studies addressing these issues are available in literature. However, longitudinal, perspective studies are lacking. Mild hyperhomocysteinaemia can be due partly to inherited susceptibility-as the homozygous carriership of the T677 variant in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR). Case-control studies have been carried out on a possible association between unexplained fetal losses and mild hyperhomocysteinaemia. Although case-control and perspective studies are available on hyperhomocysteinaemia and other gestational vascular complications the data are conflicting. Intervention studies have been carried out to prevent adverse obstetric outcomes in women with factor V Leiden or factor II A20210 mutations and previous adverse outcomes. Although these are not randomized controlled trials, all have found significantly better outcomes in treated pregnancies compared to those of untreated pregnancies in the same women.

KW - Fetal loss

KW - Hyperhomocysteinaemia

KW - Pre-eclampsia

KW - Pregnancy complications

KW - Pregnancy outcome

KW - Thrombophilia

UR - http://www.scopus.com/inward/record.url?scp=0038317610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038317610&partnerID=8YFLogxK

U2 - 10.1016/S1521-6926(03)00017-3

DO - 10.1016/S1521-6926(03)00017-3

M3 - Article

C2 - 12763495

AN - SCOPUS:0038317610

VL - 16

SP - 321

EP - 332

JO - Best Practice and Research in Clinical Haematology

JF - Best Practice and Research in Clinical Haematology

SN - 1521-6926

IS - 2

ER -