Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort

Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Enrique Esteve-Valverde, Amelia Ruffatti, Angela Tincani, Elmina Lefkou, Maria Tiziana Bertero, Gerard Espinosa, Emmanuel Coloma, Sara de Carolis, Patrizia Rovere-Querini, Valentina Canti, Elisa Picardo, Micaela Fredi, Arsene Mekinian, Anna Kuzenko, Anna Ruano, Teresa del Ross, Taisiia Melnychuk, Krista LundelinElisa Llurba, Ricard Cervera, Bettina Toth, Luis Saez-Comet, Katharina Bremme, Karoline Mayer-Pickel, Antonio Gil-Aguado

Research output: Contribution to journalArticle

Abstract

Aim: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal–foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. Methods: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. Results: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002). Conclusion: Cases with aPL-related OAPS/OMAPS showed no differences in maternal–foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalAmerican Journal of Reproductive Immunology
Volume76
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Antiphospholipid Syndrome
Thrombophilia
Obstetrics
Registries
History
Low Molecular Weight Heparin
Antiphospholipid Antibodies
Surveys and Questionnaires
Mothers
Morbidity

Keywords

  • antiphospholipid antibody
  • inherited thrombophilia
  • obstetric outcome
  • thrombosis
  • treatment

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Inherited thrombophilia in women with poor aPL-related obstetric history : prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort. / Alijotas-Reig, Jaume; Ferrer-Oliveras, Raquel; Esteve-Valverde, Enrique; Ruffatti, Amelia; Tincani, Angela; Lefkou, Elmina; Bertero, Maria Tiziana; Espinosa, Gerard; Coloma, Emmanuel; de Carolis, Sara; Rovere-Querini, Patrizia; Canti, Valentina; Picardo, Elisa; Fredi, Micaela; Mekinian, Arsene; Kuzenko, Anna; Ruano, Anna; del Ross, Teresa; Melnychuk, Taisiia; Lundelin, Krista; Llurba, Elisa; Cervera, Ricard; Toth, Bettina; Saez-Comet, Luis; Bremme, Katharina; Mayer-Pickel, Karoline; Gil-Aguado, Antonio.

In: American Journal of Reproductive Immunology, Vol. 76, No. 2, 01.08.2016, p. 164-171.

Research output: Contribution to journalArticle

Alijotas-Reig, J, Ferrer-Oliveras, R, Esteve-Valverde, E, Ruffatti, A, Tincani, A, Lefkou, E, Bertero, MT, Espinosa, G, Coloma, E, de Carolis, S, Rovere-Querini, P, Canti, V, Picardo, E, Fredi, M, Mekinian, A, Kuzenko, A, Ruano, A, del Ross, T, Melnychuk, T, Lundelin, K, Llurba, E, Cervera, R, Toth, B, Saez-Comet, L, Bremme, K, Mayer-Pickel, K & Gil-Aguado, A 2016, 'Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort', American Journal of Reproductive Immunology, vol. 76, no. 2, pp. 164-171. https://doi.org/10.1111/aji.12534
Alijotas-Reig, Jaume ; Ferrer-Oliveras, Raquel ; Esteve-Valverde, Enrique ; Ruffatti, Amelia ; Tincani, Angela ; Lefkou, Elmina ; Bertero, Maria Tiziana ; Espinosa, Gerard ; Coloma, Emmanuel ; de Carolis, Sara ; Rovere-Querini, Patrizia ; Canti, Valentina ; Picardo, Elisa ; Fredi, Micaela ; Mekinian, Arsene ; Kuzenko, Anna ; Ruano, Anna ; del Ross, Teresa ; Melnychuk, Taisiia ; Lundelin, Krista ; Llurba, Elisa ; Cervera, Ricard ; Toth, Bettina ; Saez-Comet, Luis ; Bremme, Katharina ; Mayer-Pickel, Karoline ; Gil-Aguado, Antonio. / Inherited thrombophilia in women with poor aPL-related obstetric history : prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort. In: American Journal of Reproductive Immunology. 2016 ; Vol. 76, No. 2. pp. 164-171.
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abstract = "Aim: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal–foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. Methods: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. Results: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1{\%} had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002). Conclusion: Cases with aPL-related OAPS/OMAPS showed no differences in maternal–foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.",
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AU - Ferrer-Oliveras, Raquel

AU - Esteve-Valverde, Enrique

AU - Ruffatti, Amelia

AU - Tincani, Angela

AU - Lefkou, Elmina

AU - Bertero, Maria Tiziana

AU - Espinosa, Gerard

AU - Coloma, Emmanuel

AU - de Carolis, Sara

AU - Rovere-Querini, Patrizia

AU - Canti, Valentina

AU - Picardo, Elisa

AU - Fredi, Micaela

AU - Mekinian, Arsene

AU - Kuzenko, Anna

AU - Ruano, Anna

AU - del Ross, Teresa

AU - Melnychuk, Taisiia

AU - Lundelin, Krista

AU - Llurba, Elisa

AU - Cervera, Ricard

AU - Toth, Bettina

AU - Saez-Comet, Luis

AU - Bremme, Katharina

AU - Mayer-Pickel, Karoline

AU - Gil-Aguado, Antonio

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