Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously.

C. Franceschi, C. Cevolani, F. Licastro, P. Paolucci, G. Prodi, P. Perocco

Research output: Contribution to journalArticlepeer-review

Abstract

Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.

Original languageEnglish
Pages (from-to)139-154
Number of pages16
JournalArchivio di scienze biologiche
Volume62
Issue number1-4
Publication statusPublished - Jan 1978

ASJC Scopus subject areas

  • Medicine(all)

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