Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously.

C. Franceschi, C. Cevolani, F. Licastro, P. Paolucci, G. Prodi, P. Perocco

Research output: Contribution to journalArticle

Abstract

Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.

Original languageEnglish
Pages (from-to)139-154
Number of pages16
JournalArchivio di scienze biologiche
Volume62
Issue number1-4
Publication statusPublished - Jan 1978

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Mitogens
Lipopolysaccharides
T-Lymphocytes
Phytohemagglutinins
Pokeweed Mitogens
Concanavalin A
Thymocytes
Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously. / Franceschi, C.; Cevolani, C.; Licastro, F.; Paolucci, P.; Prodi, G.; Perocco, P.

In: Archivio di scienze biologiche, Vol. 62, No. 1-4, 01.1978, p. 139-154.

Research output: Contribution to journalArticle

Franceschi, C. ; Cevolani, C. ; Licastro, F. ; Paolucci, P. ; Prodi, G. ; Perocco, P. / Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously. In: Archivio di scienze biologiche. 1978 ; Vol. 62, No. 1-4. pp. 139-154.
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