Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (α-IFN) and Ampligen (an inductor of endogenous production of α-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, α-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by α-IFN. These results suggest that α-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.
|Translated title of the contribution||Inhibition by alpha-interferon and Ampligen of human immunodeficiency virus (HIV) replication in monocyte/macrophage subpopulations|
|Number of pages||3|
|Journal||Medicina - Rivista della Enciclopedia Medica Italiana|
|Publication status||Published - 1990|
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