INHIBIZIONE DA INTERFERON ALFA E AMPLIGEN DELLA REPLICAZIONE DEL VIRUS DELL'IMMUNODEFICIENZA UMANA (HIV) IN SOTTOPOPOLAZIONI DI MONOCITO-MACROFAGI

Translated title of the contribution: Inhibition by alpha-interferon and Ampligen of human immunodeficiency virus (HIV) replication in monocyte/macrophage subpopulations

A. Bergamini, L. Ercoli, C. F. Perno

Research output: Contribution to journalArticle

Abstract

Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (α-IFN) and Ampligen (an inductor of endogenous production of α-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, α-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by α-IFN. These results suggest that α-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.

Original languageItalian
Pages (from-to)34-36
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number1
Publication statusPublished - 1990

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Virus Replication
Interferon-alpha
Monocytes
Macrophages
HIV
Virus Diseases
Antiviral Agents
poly(I).poly(c12,U)
Drug Therapy
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "INHIBIZIONE DA INTERFERON ALFA E AMPLIGEN DELLA REPLICAZIONE DEL VIRUS DELL'IMMUNODEFICIENZA UMANA (HIV) IN SOTTOPOPOLAZIONI DI MONOCITO-MACROFAGI",
abstract = "Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (α-IFN) and Ampligen (an inductor of endogenous production of α-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, α-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by α-IFN. These results suggest that α-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.",
author = "A. Bergamini and L. Ercoli and Perno, {C. F.}",
year = "1990",
language = "Italian",
volume = "10",
pages = "34--36",
journal = "Medicina - Rivista della Enciclopedia Medica Italiana",
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TY - JOUR

T1 - INHIBIZIONE DA INTERFERON ALFA E AMPLIGEN DELLA REPLICAZIONE DEL VIRUS DELL'IMMUNODEFICIENZA UMANA (HIV) IN SOTTOPOPOLAZIONI DI MONOCITO-MACROFAGI

AU - Bergamini, A.

AU - Ercoli, L.

AU - Perno, C. F.

PY - 1990

Y1 - 1990

N2 - Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (α-IFN) and Ampligen (an inductor of endogenous production of α-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, α-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by α-IFN. These results suggest that α-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.

AB - Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (α-IFN) and Ampligen (an inductor of endogenous production of α-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, α-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by α-IFN. These results suggest that α-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.

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