Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate

Raffaella Dell'Eva, Ulrich Pfeffer, Roberta Vené, Luca Anfosso, Alessandra Forlani, Adriana Albini, Thomas Efferth

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Artesunate (ART) is a semi-synthetic derivative of the sesquiterpene artemisinin used for the second line therapy of malaria infections with Plasmodium falciparum. ART also inhibits growth of many transformed cell lines. In the present investigation, we show that ART inhibited the growth of normal human umbilical endothelial cells and of KS-IMM cells that we have established from a Kaposi's sarcoma lesion obtained from a renal transplant patient. The growth inhibitory activity correlated with the induction of apoptosis in KS-IMM cells. Apoptosis was not observed in normal endothelial cells, which, however, showed drastically increased cell doubling times upon ART treatment. ART strongly reduced angiogenesis in vivo in terms of vascularization of Matrigel plugs injected subcutaneously into syngenic mice. We conclude that ART represents a promising candidate drug for the treatment of the highly angiogenic Kaposi's sarcoma. As a low-cost drug, it might be of particular interest for areas of Kaposi's sarcoma endemics. ART could be useful for the prevention of tumor angiogenesis.

Original languageEnglish
Pages (from-to)2359-2366
Number of pages8
JournalBiochemical Pharmacology
Volume68
Issue number12
DOIs
Publication statusPublished - Dec 15 2004

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Kaposi's Sarcoma
Antimalarials
Heterografts
Tumors
Growth
Neoplasms
Endothelial cells
Endothelial Cells
Apoptosis
Umbilicus
Transplants
Transformed Cell Line
Drug Costs
Sesquiterpenes
Plasmodium falciparum
artesunate
Pharmaceutical Preparations
Malaria
Therapeutics
Cells

Keywords

  • Angiogenesis
  • Apoptosis
  • Drug resistance
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. / Dell'Eva, Raffaella; Pfeffer, Ulrich; Vené, Roberta; Anfosso, Luca; Forlani, Alessandra; Albini, Adriana; Efferth, Thomas.

In: Biochemical Pharmacology, Vol. 68, No. 12, 15.12.2004, p. 2359-2366.

Research output: Contribution to journalArticle

Dell'Eva, Raffaella ; Pfeffer, Ulrich ; Vené, Roberta ; Anfosso, Luca ; Forlani, Alessandra ; Albini, Adriana ; Efferth, Thomas. / Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. In: Biochemical Pharmacology. 2004 ; Vol. 68, No. 12. pp. 2359-2366.
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