Inhibition of anti-class I cytotoxicity by anti-class II monoclonal antibodies (MoAb). II. Blocking of anti-class I CTL clones by anti-DR MoAb

Andrea Anichini, Stan Ress, Gideon Strassmann, Fritz H. Bach

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies directed at monomorphic determinants on A,B,C (w6/32) or DR (L243, S4/24, S8/8) HLA antigens were used to inhibit the cytotoxic activity of class I- or class II-reactive CTL clones. Anti-class I (HLA-Bw62) cytotoxic T lymphocyte CTL clones were inhibited by w6/32, but not by L243, when tested on PHA blasts and LCL as targets. Interestingly, S4/24 and S8/8 demonstrated a differential blocking ability of class I reactive clones; these two monoclonal antibodies could not block Bw62-directed CTL clones when using PHA blasts as targets but strongly inhibited the cytotoxic activity of the same clones on LCLs as targets.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalHuman Immunology
Volume13
Issue number2
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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