Inhibition of anti-class I cytotoxicity by anti-class II monoclonal antibodies (MoAb). II. Blocking of anti-class I CTL clones by anti-DR MoAb

Andrea Anichini, Stan Ress, Gideon Strassmann, Fritz H. Bach

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Abstract

Monoclonal antibodies directed at monomorphic determinants on A,B,C (w6/32) or DR (L243, S4/24, S8/8) HLA antigens were used to inhibit the cytotoxic activity of class I- or class II-reactive CTL clones. Anti-class I (HLA-Bw62) cytotoxic T lymphocyte CTL clones were inhibited by w6/32, but not by L243, when tested on PHA blasts and LCL as targets. Interestingly, S4/24 and S8/8 demonstrated a differential blocking ability of class I reactive clones; these two monoclonal antibodies could not block Bw62-directed CTL clones when using PHA blasts as targets but strongly inhibited the cytotoxic activity of the same clones on LCLs as targets.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalHuman Immunology
Volume13
Issue number2
DOIs
Publication statusPublished - 1985

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Clone Cells
Monoclonal Antibodies
Cytotoxic T-Lymphocytes
HLA Antigens

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Inhibition of anti-class I cytotoxicity by anti-class II monoclonal antibodies (MoAb). II. Blocking of anti-class I CTL clones by anti-DR MoAb. / Anichini, Andrea; Ress, Stan; Strassmann, Gideon; Bach, Fritz H.

In: Human Immunology, Vol. 13, No. 2, 1985, p. 139-143.

Research output: Contribution to journalArticle

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