Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci

Anna Saran, Daniela Zaffaroni, Simonetta Pazzaglia, Bernard Peissel, Federica Galbiati, Monica Spinola, Giacomo Manenti, Nicola Zanesi, Simonetta Rebessi, Maria Teresa Mancuso, Vincenzo Covelli, Tommaso A. Dragani

Research output: Contribution to journalArticlepeer-review


The Car-R outbred mouse line was phenotypically selected for high resistance to two-stage skin tumorigenesis. In the present study we tested the hypothesis that a subset of genetic loci responsible for resistance to skin tumorigenesis of Car-R mice might also inhibit lung tumorigenesis. Skin and lung tumorigenesis were induced in groups of Car-R, SWR/J, (SWR/JxCar-R)FI and SWR/Jx(SWR/JxCar-R) backcross mice by i.p. urethane initiation and skin TPA promotion. Car-R mice showed a much lower susceptibility to both skin and lung tumorigenesis as compared to SWR/J mice, which are susceptible to both lung and skin tumorigenesis. The Car-R-inherited genome significantly inhibited both skin and lung cancer development in the FI progeny of Car-R with SWR/J mice. In the backcross population, skin and lung tumor phenotypes showed a statistically significant correlation, indicating that a subset of the cancer resistance alleles, which segregated in the Car-R line during selection for resistance to skin carcinogenesis, provides resistance to both skin and lung tumorigenesis.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalInternational Journal of Cancer
Issue number5
Publication statusPublished - Feb 10 2002


  • Cancer modifiers
  • Genetic susceptibility
  • Inherited predisposition
  • Kras2 linkage disequilibrium
  • Lung neoplasm
  • PthIh

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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