Inhibition of caspases maintains the antineoplastic function of γδ T cells repeatedly challenged with lymphoma cells

M. Ferrarini, G. Consogno, P. Rovere, C. Sciorati, L. Dagna, D. Resta, C. Rugarli, A. A. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

T lymphocytes recognizing tumor antigens eventually undergo anergy or Fas-mediated death. Vγ9/Vδ2+ T cells recognize poorly characterized ligand moieties on human B-cell lymphomas. Here we show that γδ T cells, a model for the study of activation-induced apoptosis, activate on repeated in vitro antigen-recognition caspase 3 and 8 and dramatically down-regulate their cytotoxic and secretory function. Caspase hindrance enhanced γδ T cell survival and sustained the killing of neoplastic cells and the release of IFN-γ and tumor necrosis factor α. Caspases of tumor-specific T cells represent a candidate target to complement adoptive immunotherapy strategies.

Original languageEnglish
Pages (from-to)3092-3095
Number of pages4
JournalCancer Research
Volume61
Issue number7
Publication statusPublished - Apr 1 2001

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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