Abstract
T lymphocytes recognizing tumor antigens eventually undergo anergy or Fas-mediated death. Vγ9/Vδ2+ T cells recognize poorly characterized ligand moieties on human B-cell lymphomas. Here we show that γδ T cells, a model for the study of activation-induced apoptosis, activate on repeated in vitro antigen-recognition caspase 3 and 8 and dramatically down-regulate their cytotoxic and secretory function. Caspase hindrance enhanced γδ T cell survival and sustained the killing of neoplastic cells and the release of IFN-γ and tumor necrosis factor α. Caspases of tumor-specific T cells represent a candidate target to complement adoptive immunotherapy strategies.
Original language | English |
---|---|
Pages (from-to) | 3092-3095 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 61 |
Issue number | 7 |
Publication status | Published - Apr 1 2001 |
ASJC Scopus subject areas
- Cancer Research
- Oncology