(D)-Ribose and deoxy-(D)-ribose inhibited DNA, RNA and protein synthesis in a wide variety of cells (dividing and nondividing, normal and neoplastic, freely floating and substrate adhering, human and murine) at concentrations at which other monosaccharides have little or no effect. Inhibition was irreversible and proportional to the sugar concentration and time of contact. However, the first effects were seen only after 24 hr of incubation and progressed slowly to cell death. Whether the two sugars share the same mechanisms of action is not known. In any case, they deeply derange metabolic process in both dividing and nondividing cells.
|Number of pages||12|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)