Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo

Ciro Indolfi, Enrico V. Awedimento, Antonio Rapacciuolo, Emilio Di Lorenzo, Giovanni Esposito, Eugenio Stabile, Antonio Feliciello, Evelina Mele, Paola Giuliano, Gianluigi Condorelli, Massimo Chiariello

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Abstract

Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in many cell types. We investigated the role of ras proteins in the vascular response to arterial injury by inactivating cellular ras of rats in which the common carotid artery was subjected to balloon injury. DNA vectors expressing ras transdominant negative mutants, which interfere with ras function, reduced neo-intimal formation after injury. Our results indicate a key role for ras in smooth muscle cell proliferation and show that the local delivery of transdominant negative mutants of ras in vivo might prevent some of the acute vascular injury caused by balloon injury.

Original languageEnglish
Pages (from-to)545
Number of pages1
JournalNature Medicine
Volume1
Issue number6
DOIs
Publication statusPublished - 1995

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Indolfi, C., Awedimento, E. V., Rapacciuolo, A., Lorenzo, E. D., Esposito, G., Stabile, E., Feliciello, A., Mele, E., Giuliano, P., Condorelli, G., & Chiariello, M. (1995). Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Medicine, 1(6), 545. https://doi.org/10.1038/nm0695-541