Inhibition of CO2 combination and reduction of the bohr effect in haemoglobin chemically modified at its α-amino groups

J. V. Kilmartin, L. Rossi-Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
JournalNature
Volume222
Issue number5200
DOIs
Publication statusPublished - 1969

ASJC Scopus subject areas

  • General

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