Inhibition of CO2 combination and reduction of the bohr effect in haemoglobin chemically modified at its α-amino groups

J. V. Kilmartin; L. Rossi-Bernardi

doi:10.1038/2221243a0

Inhibition of CO2 combination and reduction of the bohr effect in haemoglobin chemically modified at its α-amino groups

J. V. Kilmartin, L. Rossi-Bernardi

IRCCS Multimedica

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Abstract

Blocking of the α-amino groups by cyanate inhibits the uptake of CO₂ by haemoglobin. It also inhibits the influence which changes in pCO₂ at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.

Original language	English
Pages (from-to)	1243-1246
Number of pages	4
Journal	Nature
Volume	222
Issue number	5200
DOIs	https://doi.org/10.1038/2221243a0
Publication status	Published - 1969

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title = "Inhibition of CO2 combination and reduction of the bohr effect in haemoglobin chemically modified at its α-amino groups",

abstract = "Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.",

author = "Kilmartin, {J. V.} and L. Rossi-Bernardi",

year = "1969",

doi = "10.1038/2221243a0",

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journal = "Nature",

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AU - Rossi-Bernardi, L.

PY - 1969

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N2 - Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.

AB - Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.

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Inhibition of CO2 combination and reduction of the bohr effect in haemoglobin chemically modified at its α-amino groups

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