Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene

R. Ghidoni; L. Gasparini; A. Alberici; L. Benussi; L. Barbiero; F. Mazzoli; F. Nicosia; D. Finazzi; L. Benerini Gatta; A. Albertini; O. Zanetti; G. Binetti

doi:10.1007/s00702-003-0015-9

Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene

R. Ghidoni, L. Gasparini, A. Alberici, L. Benussi, L. Barbiero, F. Mazzoli, F. Nicosia, D. Finazzi, L. Benerini Gatta, A. Albertini, O. Zanetti, G. Binetti

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Defects in energy metabolism and oxidative stress play an important role in the pathogenesis of Alzheimer's Disease (AD). In sporadic AD cases, presenilin 2 (PS2) mRNA levels are decreased in brain areas affected by the disease. The aim of the present study was to investigate whether mitochondrial dysfunction might influence PS2 gene expression. We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity. No one of the analyzed transcription factors, sensitive to redox status of the cell, could explain this effect. Azide effect on PS2 expression was completely inhibited by the addition of an antioxidant suggesting that the imbalance of the cellular redox homeostasis modulates the expression of this gene.

Original language	English
Pages (from-to)	1029-1039
Number of pages	11
Journal	Journal of Neural Transmission
Volume	110
Issue number	9
DOIs	https://doi.org/10.1007/s00702-003-0015-9
Publication status	Published - Sep 1 2003

Keywords

Nonradioactive RPA
Oxidative stress
PS2 expression

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1007/s00702-003-0015-9

Fingerprint Dive into the research topics of 'Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene'. Together they form a unique fingerprint.

Cite this

Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene. / Ghidoni, R.; Gasparini, L.; Alberici, A.; Benussi, L.; Barbiero, L.; Mazzoli, F.; Nicosia, F.; Finazzi, D.; Gatta, L. Benerini; Albertini, A.; Zanetti, O.; Binetti, G.

In: Journal of Neural Transmission, Vol. 110, No. 9, 01.09.2003, p. 1029-1039.

Research output: Contribution to journal › Article › peer-review

@article{8201b41fda584e9b9b61c73898df877b,

title = "Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene",

abstract = "Defects in energy metabolism and oxidative stress play an important role in the pathogenesis of Alzheimer's Disease (AD). In sporadic AD cases, presenilin 2 (PS2) mRNA levels are decreased in brain areas affected by the disease. The aim of the present study was to investigate whether mitochondrial dysfunction might influence PS2 gene expression. We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity. No one of the analyzed transcription factors, sensitive to redox status of the cell, could explain this effect. Azide effect on PS2 expression was completely inhibited by the addition of an antioxidant suggesting that the imbalance of the cellular redox homeostasis modulates the expression of this gene.",

keywords = "Nonradioactive RPA, Oxidative stress, PS2 expression",

author = "R. Ghidoni and L. Gasparini and A. Alberici and L. Benussi and L. Barbiero and F. Mazzoli and F. Nicosia and D. Finazzi and Gatta, {L. Benerini} and A. Albertini and O. Zanetti and G. Binetti",

year = "2003",

month = sep,

day = "1",

doi = "10.1007/s00702-003-0015-9",

language = "English",

volume = "110",

pages = "1029--1039",

journal = "Journal of Neuro-Visceral Relations",

issn = "0375-9245",

publisher = "Springer-Verlag Wien",

number = "9",

}

TY - JOUR

T1 - Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene

AU - Ghidoni, R.

AU - Gasparini, L.

AU - Alberici, A.

AU - Benussi, L.

AU - Barbiero, L.

AU - Mazzoli, F.

AU - Nicosia, F.

AU - Finazzi, D.

AU - Gatta, L. Benerini

AU - Albertini, A.

AU - Zanetti, O.

AU - Binetti, G.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Defects in energy metabolism and oxidative stress play an important role in the pathogenesis of Alzheimer's Disease (AD). In sporadic AD cases, presenilin 2 (PS2) mRNA levels are decreased in brain areas affected by the disease. The aim of the present study was to investigate whether mitochondrial dysfunction might influence PS2 gene expression. We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity. No one of the analyzed transcription factors, sensitive to redox status of the cell, could explain this effect. Azide effect on PS2 expression was completely inhibited by the addition of an antioxidant suggesting that the imbalance of the cellular redox homeostasis modulates the expression of this gene.

AB - Defects in energy metabolism and oxidative stress play an important role in the pathogenesis of Alzheimer's Disease (AD). In sporadic AD cases, presenilin 2 (PS2) mRNA levels are decreased in brain areas affected by the disease. The aim of the present study was to investigate whether mitochondrial dysfunction might influence PS2 gene expression. We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity. No one of the analyzed transcription factors, sensitive to redox status of the cell, could explain this effect. Azide effect on PS2 expression was completely inhibited by the addition of an antioxidant suggesting that the imbalance of the cellular redox homeostasis modulates the expression of this gene.

KW - Nonradioactive RPA

KW - Oxidative stress

KW - PS2 expression

UR - http://www.scopus.com/inward/record.url?scp=10744226331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744226331&partnerID=8YFLogxK

U2 - 10.1007/s00702-003-0015-9

DO - 10.1007/s00702-003-0015-9

M3 - Article

C2 - 12938025

AN - SCOPUS:10744226331

VL - 110

SP - 1029

EP - 1039

JO - Journal of Neuro-Visceral Relations

JF - Journal of Neuro-Visceral Relations

SN - 0375-9245

IS - 9

ER -