Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site

S. Bretti, P. Neri, L. Lozzi, M. Rustici, P. Comoglio, F. Giancotti, G. Tarone

Research output: Contribution to journalArticle

Abstract

We have analyzed the effect of the synthetic oligopeptides Gly-Arg-Gly-Asp-Ser-Pro (GRSDSP) and Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), analogues to the fibronectin cell-binding sequence, on the formation of experimental lung metastasis. SR-BALB were injected alone or in conjunction with GRGDSP or GRGESP in the tail vein of BALB/c mice. Co-injection with GRGESP reduced by approximately 70% the number of metastatic colonies per mouse. However, co-injection with the closely related peptide GRGDSP, containing the conservative substitution Glu/Asp, did not affect metastatic behavior. GRGESP peptide anti-metastatic activity was not due to a toxic effect on tumor cells or on mice. In vitro adhesion assays testing for possible effect of the peptide on cell-matrix interactions indicated that the GRGESP peptide did not affect cell adhesion to the matrix proteins tested.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalInternational Journal of Cancer
Volume43
Issue number1
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bretti, S., Neri, P., Lozzi, L., Rustici, M., Comoglio, P., Giancotti, F., & Tarone, G. (1989). Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site. International Journal of Cancer, 43(1), 102-106.