Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site

S. Bretti, P. Neri, L. Lozzi, M. Rustici, P. Comoglio, F. Giancotti, G. Tarone

Research output: Contribution to journalArticle

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Abstract

We have analyzed the effect of the synthetic oligopeptides Gly-Arg-Gly-Asp-Ser-Pro (GRSDSP) and Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), analogues to the fibronectin cell-binding sequence, on the formation of experimental lung metastasis. SR-BALB were injected alone or in conjunction with GRGDSP or GRGESP in the tail vein of BALB/c mice. Co-injection with GRGESP reduced by approximately 70% the number of metastatic colonies per mouse. However, co-injection with the closely related peptide GRGDSP, containing the conservative substitution Glu/Asp, did not affect metastatic behavior. GRGESP peptide anti-metastatic activity was not due to a toxic effect on tumor cells or on mice. In vitro adhesion assays testing for possible effect of the peptide on cell-matrix interactions indicated that the GRGESP peptide did not affect cell adhesion to the matrix proteins tested.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalInternational Journal of Cancer
Volume43
Issue number1
Publication statusPublished - 1989

Fingerprint

glycyl-arginyl-glycyl-glutamyl-seryl-proline
Oligopeptides
Fibrosarcoma
Fibronectins
glycyl-arginyl-glycyl-aspartyl-seryl-proline
Binding Sites
Neoplasm Metastasis
Peptides
Cell-Matrix Junctions
Injections
Poisons
Cell Communication
Inhibition (Psychology)
Tail
Veins
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bretti, S., Neri, P., Lozzi, L., Rustici, M., Comoglio, P., Giancotti, F., & Tarone, G. (1989). Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site. International Journal of Cancer, 43(1), 102-106.

Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site. / Bretti, S.; Neri, P.; Lozzi, L.; Rustici, M.; Comoglio, P.; Giancotti, F.; Tarone, G.

In: International Journal of Cancer, Vol. 43, No. 1, 1989, p. 102-106.

Research output: Contribution to journalArticle

Bretti, S, Neri, P, Lozzi, L, Rustici, M, Comoglio, P, Giancotti, F & Tarone, G 1989, 'Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site', International Journal of Cancer, vol. 43, no. 1, pp. 102-106.
Bretti, S. ; Neri, P. ; Lozzi, L. ; Rustici, M. ; Comoglio, P. ; Giancotti, F. ; Tarone, G. / Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site. In: International Journal of Cancer. 1989 ; Vol. 43, No. 1. pp. 102-106.
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AU - Comoglio, P.

AU - Giancotti, F.

AU - Tarone, G.

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