Inhibition of FasL sustains phagocytic cells and delays myogenesis in regenerating muscle fibers

Marco Sandri, Claudia Sandri, Barbara Brun, Emanuele Giurisato, Marcello Cantini, Katia Rossini, Chiara Destro, Paola Arslan, Ugo Carraro

Research output: Contribution to journalArticle

Abstract

Macrophage-muscle cell interactions are complex, and the majority is unknown. The persistence of inflammatory cells in skeletal muscle could be critical for myofiber viability. In the present paper, we show that FasL plays a role in the resolution of muscle inflammation. We analyzed inflamed muscles of normal mice treated from day 3 to day 8 with a FasL inhibitor (Fas-Ig) or with control Ig. Treated muscles were collected at 3, 5, and 10 days. The treatment with recombinant Fas-Ig protein induced a severe persistence of inflammatory cells at 5 days (115,000±27,838 vs. 41,661±6848, p

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalJournal of Leukocyte Biology
Volume69
Issue number3
Publication statusPublished - 2001

Keywords

  • Apoptosis
  • Differentiation
  • Inflammation
  • Myoblast

ASJC Scopus subject areas

  • Cell Biology

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