Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir

P. Franchetti, L. Cappellacci, R. Petrelli, P. Vita, M. Grifantini, L. Rossi, F. Pierigé, S. Serafini, M. Magnani, E. Balestra, C. F. Perno

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Homo- and heterodimers of nucleoside/nucleotide analogues as reverse transcriptase inhibitors are effective on HIV-1-infected human monocyte-derived macrophages (M/M) compared to the single drugs or their combination. Since the combined treatment of lamivudine (3TC) and tenofovir ((R)PMPA) has an antiretroviral efficacy and a synergic effect respect to separate drugs, the heterodinucleotide 3TCpPMPA was synthesized. A single administration of the dimer as free drug or 3TCpPMPA-loaded RBC selectively targeted to M/M was able to almost completely protect macrophages from "de novo" infection.

Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number8-9
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Tenofovir
Lamivudine
Macrophages
HIV-1
Blood
Erythrocytes
Cells
Pharmaceutical Preparations
Reverse Transcriptase Inhibitors
Hominidae
Nucleosides
Dimers
Nucleotides
Infection

Keywords

  • Anti-HIV-1 activity
  • Heterodinucleotides
  • Human macrophages

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir. / Franchetti, P.; Cappellacci, L.; Petrelli, R.; Vita, P.; Grifantini, M.; Rossi, L.; Pierigé, F.; Serafini, S.; Magnani, M.; Balestra, E.; Perno, C. F.

In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 26, No. 8-9, 08.2007, p. 953-957.

Research output: Contribution to journalArticle

Franchetti, P, Cappellacci, L, Petrelli, R, Vita, P, Grifantini, M, Rossi, L, Pierigé, F, Serafini, S, Magnani, M, Balestra, E & Perno, CF 2007, 'Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir', Nucleosides, Nucleotides and Nucleic Acids, vol. 26, no. 8-9, pp. 953-957. https://doi.org/10.1080/15257770701508067
Franchetti, P. ; Cappellacci, L. ; Petrelli, R. ; Vita, P. ; Grifantini, M. ; Rossi, L. ; Pierigé, F. ; Serafini, S. ; Magnani, M. ; Balestra, E. ; Perno, C. F. / Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir. In: Nucleosides, Nucleotides and Nucleic Acids. 2007 ; Vol. 26, No. 8-9. pp. 953-957.
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