Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

Paolo Fruscella; Maria Romano; Diego Albani; Sergio Bernasconi; Walter Luini; Alessandra Bruno; Mario Salmona; Luisa Diomede

doi:10.1006/cyto.1999.0602

Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

Paolo Fruscella, Maria Romano, Diego Albani, Sergio Bernasconi, Walter Luini, Alessandra Bruno, Mario Salmona, Luisa Diomede

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	1100-1103
Number of pages	4
Journal	Cytokine
Volume	12
Issue number	7
DOIs	https://doi.org/10.1006/cyto.1999.0602
Publication status	Published - Jul 2000

Keywords

Chemokines
Cholesterol
HMG-CoA reductase
MCP-1
Rodent

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Immunology
Immunology and Allergy

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10.1006/cyto.1999.0602

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Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production. / Fruscella, Paolo; Romano, Maria; Albani, Diego; Bernasconi, Sergio; Luini, Walter; Bruno, Alessandra; Salmona, Mario ; Diomede, Luisa.

In: Cytokine, Vol. 12, No. 7, 07.2000, p. 1100-1103.

Research output: Contribution to journal › Article › peer-review

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AU - Luini, Walter

AU - Bruno, Alessandra

AU - Salmona, Mario

AU - Diomede, Luisa

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AB - To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

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Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

Abstract

Keywords

ASJC Scopus subject areas

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