Abstract
To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.
Original language | English |
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Pages (from-to) | 1100-1103 |
Number of pages | 4 |
Journal | Cytokine |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2000 |
Keywords
- Chemokines
- Cholesterol
- HMG-CoA reductase
- MCP-1
- Rodent
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Immunology
- Immunology and Allergy