Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

Paolo Fruscella, Maria Romano, Diego Albani, Sergio Bernasconi, Walter Luini, Alessandra Bruno, Mario Salmona, Luisa Diomede

Research output: Contribution to journalArticlepeer-review

Abstract

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)1100-1103
Number of pages4
JournalCytokine
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2000

Keywords

  • Chemokines
  • Cholesterol
  • HMG-CoA reductase
  • MCP-1
  • Rodent

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

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