Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

Susanna Colli, Marina Marinovich, Eduardo Stragliotto, Corrado L. Galli, Elena Tremoli

Research output: Contribution to journalArticlepeer-review

Abstract

Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.

Original languageEnglish
Pages (from-to)3909-3912
Number of pages4
JournalBiochemical Pharmacology
Volume38
Issue number22
DOIs
Publication statusPublished - Nov 15 1989

ASJC Scopus subject areas

  • Pharmacology

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