Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

Susanna Colli; Marina Marinovich; Eduardo Stragliotto; Corrado L. Galli; Elena Tremoli

doi:10.1016/0006-2952(89)90667-9

Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

Susanna Colli, Marina Marinovich, Eduardo Stragliotto, Corrado L. Galli, Elena Tremoli

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B₄ formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B₄ synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.

Original language	English
Pages (from-to)	3909-3912
Number of pages	4
Journal	Biochemical Pharmacology
Volume	38
Issue number	22
DOIs	https://doi.org/10.1016/0006-2952(89)90667-9
Publication status	Published - Nov 15 1989

ASJC Scopus subject areas

Pharmacology

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title = "Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization",

abstract = "Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.",

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T1 - Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

AU - Colli, Susanna

AU - Marinovich, Marina

AU - Stragliotto, Eduardo

AU - Galli, Corrado L.

AU - Tremoli, Elena

PY - 1989/11/15

Y1 - 1989/11/15

N2 - Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.

AB - Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.

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