TY - JOUR
T1 - Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization
AU - Colli, Susanna
AU - Marinovich, Marina
AU - Stragliotto, Eduardo
AU - Galli, Corrado L.
AU - Tremoli, Elena
PY - 1989/11/15
Y1 - 1989/11/15
N2 - Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.
AB - Albumin, at concentration normally present in plasma (∼600 μM), signicantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.
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U2 - 10.1016/0006-2952(89)90667-9
DO - 10.1016/0006-2952(89)90667-9
M3 - Article
C2 - 2557035
AN - SCOPUS:0024368614
VL - 38
SP - 3909
EP - 3912
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 22
ER -