Abstract
Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.
| Original language | English |
|---|---|
| Pages (from-to) | 749-751 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 42 |
| Issue number | 5 |
| Publication status | Published - 1973 |
ASJC Scopus subject areas
- Hematology
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Cite this
Donati, M. B., De Gaetano, G., Vermylen, J., & Verstraete, M. (1973). Inhibition of human platelet aggregation by plasmin digests of human factor VIII. Blood, 42(5), 749-751.