Inhibition of human platelet aggregation by plasmin digests of human factor VIII

M. B. Donati, G. De Gaetano, J. Vermylen, M. Verstraete

Research output: Contribution to journalArticle

Abstract

Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

Original languageEnglish
Pages (from-to)749-751
Number of pages3
JournalBlood
Volume42
Issue number5
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Hematology

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