Inhibition of human platelet aggregation by plasmin digests of human factor VIII

M. B. Donati; G. De Gaetano; J. Vermylen; M. Verstraete

Inhibition of human platelet aggregation by plasmin digests of human factor VIII

M. B. Donati, G. De Gaetano, J. Vermylen, M. Verstraete

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Abstract

Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

Original language	English
Pages (from-to)	749-751
Number of pages	3
Journal	Blood
Volume	42
Issue number	5
Publication status	Published - 1973

ASJC Scopus subject areas

Hematology

Cite this

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title = "Inhibition of human platelet aggregation by plasmin digests of human factor VIII",

abstract = "Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.",

author = "Donati, {M. B.} and {De Gaetano}, G. and J. Vermylen and M. Verstraete",

year = "1973",

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AU - Vermylen, J.

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PY - 1973

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N2 - Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

AB - Human factor VIII, upon prolonged incubation at 37° C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and this could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

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Inhibition of human platelet aggregation by plasmin digests of human factor VIII

Abstract

ASJC Scopus subject areas

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