Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries

Armando Ialenti, Gianluca Grassia, Peter Gordon, Marcella Maddaluno, Maria Vittoria Di Lauro, Andrew H. Baker, Angelo Guglielmotti, Antonio Colombo, Giuseppe Biondi, Simon Kennedy, Pasquale Maffia

Research output: Contribution to journalArticle

Abstract

Objective-: We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth muscle cell proliferation and migration and neointimal macrophage content, effects associated with the inhibition of MCP-1/CCL2 production. The aim of the current study was to evaluate the efficacy of bindarit on in-stent stenosis in the preclinical porcine coronary stent model. Methods and Results-: One or 2 bare metal stents (Multi-Link Vision, 3.5 mm) were deployed (1:1.2 oversize ratio) in the coronary arteries of 42 pigs (20 bindarit versus 22 controls). Bindarit (50 mg/kg per day) was administered orally from 2 days before stenting until the time of euthanasia at 7 and 28 days. Bindarit caused a significant reduction in neointimal area (39.4%, P

Original languageEnglish
Pages (from-to)2448-2454
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • bindarit
  • pharmacology
  • restenosis
  • stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ialenti, A., Grassia, G., Gordon, P., Maddaluno, M., Di Lauro, M. V., Baker, A. H., Guglielmotti, A., Colombo, A., Biondi, G., Kennedy, S., & Maffia, P. (2011). Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), 2448-2454. https://doi.org/10.1161/ATVBAHA.111.230078