Inhibition of influenza A virus replication by resveratrol

Anna T. Palamara, Lucia Nencioni, Katia Aquilano, Giovanna De Chiara, Leyanis Hernandez, Federico Cozzolino, Maria R. Ciriolo, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo. We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus-infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug.

Original languageEnglish
Pages (from-to)1719-1729
Number of pages11
JournalJournal of Infectious Diseases
Volume191
Issue number10
DOIs
Publication statusPublished - May 15 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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