Inhibition of influenza H5N1 invasion by modified heparin derivatives

Mark A. Skidmore, Anna Kajaste-Rudnitski, Nicola M. Wells, Scott E. Guimond, Timothy R. Rudd, Edwin A. Yates, Elisa Vicenzi

Research output: Contribution to journalArticle

Abstract

Influenza remains a serious health threat, with resistance to frontline drugs becoming more common, and new treatments urgently sought. One strategy for the inhibition of the attachment of influenza to host cells is to employ chemically modified heparins, capable of effectively competing with the multivalent interactions involved. In an assay of H5N1 influenza viral invasion comprising a H5 pseudotyped HIV system, selective removal of the sulfate groups from heparin (IC50 ~22 × 10-9 g mL-1) allowed the retention of inhibitory activity in the products (IC50 ~4 × 10-9 g mL-1) while significantly reducing their anticoagulant activities. Chemically modified anionic polysaccharides offer a potential source of effective inhibitors of viral attachment, which are suitable for further optimisation. This journal is

Original languageEnglish
Pages (from-to)640-646
Number of pages7
JournalMedChemComm
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Human Influenza
Heparin
Derivatives
Inhibitory Concentration 50
Anticoagulants
Sulfates
Polysaccharides
Assays
Health
HIV
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Inhibition of influenza H5N1 invasion by modified heparin derivatives. / Skidmore, Mark A.; Kajaste-Rudnitski, Anna; Wells, Nicola M.; Guimond, Scott E.; Rudd, Timothy R.; Yates, Edwin A.; Vicenzi, Elisa.

In: MedChemComm, Vol. 6, No. 4, 01.04.2015, p. 640-646.

Research output: Contribution to journalArticle

Skidmore, Mark A. ; Kajaste-Rudnitski, Anna ; Wells, Nicola M. ; Guimond, Scott E. ; Rudd, Timothy R. ; Yates, Edwin A. ; Vicenzi, Elisa. / Inhibition of influenza H5N1 invasion by modified heparin derivatives. In: MedChemComm. 2015 ; Vol. 6, No. 4. pp. 640-646.
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