Inhibition of intestinal motility and secretion by flavonoids in mice and rats: Structure-activity relationships

G. Di Carlo, G. Autore, A. A. Izzo, P. Maiolino, N. Mascolo, P. Viola, M. V. Diurno, F. Capasso

Research output: Contribution to journalArticlepeer-review

Abstract

Intraperitoneal administration of some flavonoids (apigenin, flavone, kaempferol, morin, myricetin, naringin and rutin; 12.5-50 mg kg-1) significantly (P <0.05-0.01) reduced small (28-69%) and large (83-134%) intestinal transit in mice. Other flavonoids (naringenin, silibinin, silymarin and taxifolin, 100-200 mg kg-1) reduced (23-41%; P <0.5-0.01) intestinal transit at doses of 100-200 mg kg-1 while hesperitin, catechin and phloridzin (up to 200 mg kg-1) had no effect. This effect was antagonized by yohimbine (87-96%) and phentolamine (87-91%) but not by prazosin, propranolol, atropine, hexamethonium, mepyramine, cyproheptadine and naloxone. Yohimbine (92-96%) also antagonized the inhibitory effect of flavonols (12.5-50 mg kg-1) (P <0.05-0.01) on intraluminal accumulation of fluid and diarrhoea induced by castor oil. By contrast, verapamil potentiated the flavonol effect. It is suggested that these effects, influenced by the structure of the molecules, are mediated by α2-adrenergic receptors and calcium.

Original languageEnglish
Pages (from-to)1054-1059
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume45
Issue number12
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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