Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides

Francesco Peri, Francesca Granucci, Barbara Costa, Ivan Zanoni, Chiara Marinzi, Francesco Nicotra

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor.

Original languageEnglish
Pages (from-to)3308-3312
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number18
DOIs
Publication statusPublished - 2007

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Keywords

  • Biological activity
  • Carbohydrates
  • Drug design
  • Immunology
  • Medicinal chemistry

ASJC Scopus subject areas

  • Chemistry(all)

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