Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide

J. Pachecka, M. Salmona, G. Belvedere, L. Cantoni, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

Abstract

Cyproheptadine epoxide is a competitive inhibitor or rat liver microsomal epoxide hydrase with an apparent K1-value of 0.75 mM. Cyclobenzaprine and its epoxide stimulate in vitro the activity of this enzyme, whereas cyproheptadine, carbamazepine and carbamazepine epoxide have no effect.

Original languageEnglish
Pages (from-to)484-485
Number of pages2
JournalExperientia
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 1977

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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