Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide

J. Pachecka, M. Salmona, G. Belvedere, L. Cantoni, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cyproheptadine epoxide is a competitive inhibitor or rat liver microsomal epoxide hydrase with an apparent K1-value of 0.75 mM. Cyclobenzaprine and its epoxide stimulate in vitro the activity of this enzyme, whereas cyproheptadine, carbamazepine and carbamazepine epoxide have no effect.

Original languageEnglish
Pages (from-to)484-485
Number of pages2
JournalExperientia
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 1977

Fingerprint

Cyproheptadine
Epoxide Hydrolases
Epoxy Compounds
Liver
Carbamazepine
Rats
Enzymes
cyclobenzaprine
carbamazepine epoxide
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide. / Pachecka, J.; Salmona, M.; Belvedere, G.; Cantoni, L.; Mussini, E.; Garattini, S.

In: Experientia, Vol. 33, No. 4, 04.1977, p. 484-485.

Research output: Contribution to journalArticle

Pachecka, J. ; Salmona, M. ; Belvedere, G. ; Cantoni, L. ; Mussini, E. ; Garattini, S. / Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide. In: Experientia. 1977 ; Vol. 33, No. 4. pp. 484-485.
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